Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 961734..962359 Replicon chromosome
Accession NZ_CP090545
Organism Salmonella enterica strain 2017028-SE

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag L0F57_RS04715 Protein ID WP_000911336.1
Coordinates 961961..962359 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag L0F57_RS04710 Protein ID WP_000557549.1
Coordinates 961734..961961 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F57_RS04680 (956779) 956779..958296 + 1518 WP_000003339.1 lysine--tRNA ligase -
L0F57_RS04685 (958372) 958372..958917 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
L0F57_RS04690 (959182) 959182..959940 + 759 WP_000244329.1 amidase activator ActS -
L0F57_RS04700 (960225) 960225..961031 - 807 WP_010989071.1 DUF1460 domain-containing protein -
L0F57_RS04705 (961306) 961306..961557 - 252 WP_001540858.1 hypothetical protein -
L0F57_RS04710 (961734) 961734..961961 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
L0F57_RS04715 (961961) 961961..962359 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
L0F57_RS04720 (963165) 963165..963701 + 537 WP_001038506.1 STM3031 family outer membrane protein -
L0F57_RS04725 (963748) 963748..964380 + 633 WP_000835265.1 YfdX family protein -
L0F57_RS04730 (965099) 965099..965683 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 960225..971550 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T231147 WP_000911336.1 NZ_CP090545:961961-962359 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T231147 NZ_CP126085:278774-279124 [Peribacillus frigoritolerans]
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTTGGTTCAGAGCAGGGTGGGACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACACATGTTGAGATTAATGCAAAAAAGTACGGATTCGAGCGGGATTCCGTCATTTTATTAGAACAGATC
CGGACAATTGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAAAAAGTCAATGAAGCTTT
GCAAATTAGTCTAGGCCTCATTGAGTTTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT231147 WP_000557549.1 NZ_CP090545:961734-961961 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT231147 NZ_CP126085:278485-278766 [Peribacillus frigoritolerans]
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGATGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATTGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAGGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References