Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 961734..962359 | Replicon | chromosome |
Accession | NZ_CP090545 | ||
Organism | Salmonella enterica strain 2017028-SE |
Toxin (Protein)
Gene name | vapC | Uniprot ID | M7SD17 |
Locus tag | L0F57_RS04715 | Protein ID | WP_000911336.1 |
Coordinates | 961961..962359 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | M7S3S8 |
Locus tag | L0F57_RS04710 | Protein ID | WP_000557549.1 |
Coordinates | 961734..961961 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L0F57_RS04680 (956779) | 956779..958296 | + | 1518 | WP_000003339.1 | lysine--tRNA ligase | - |
L0F57_RS04685 (958372) | 958372..958917 | - | 546 | WP_000133994.1 | isopentenyl-diphosphate Delta-isomerase | - |
L0F57_RS04690 (959182) | 959182..959940 | + | 759 | WP_000244329.1 | amidase activator ActS | - |
L0F57_RS04700 (960225) | 960225..961031 | - | 807 | WP_010989071.1 | DUF1460 domain-containing protein | - |
L0F57_RS04705 (961306) | 961306..961557 | - | 252 | WP_001540858.1 | hypothetical protein | - |
L0F57_RS04710 (961734) | 961734..961961 | + | 228 | WP_000557549.1 | toxin-antitoxin system antitoxin VapB | Antitoxin |
L0F57_RS04715 (961961) | 961961..962359 | + | 399 | WP_000911336.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
L0F57_RS04720 (963165) | 963165..963701 | + | 537 | WP_001038506.1 | STM3031 family outer membrane protein | - |
L0F57_RS04725 (963748) | 963748..964380 | + | 633 | WP_000835265.1 | YfdX family protein | - |
L0F57_RS04730 (965099) | 965099..965683 | + | 585 | WP_001244638.1 | fimbrial protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 960225..971550 | 11325 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14938.30 Da Isoelectric Point: 7.2155
>T231147 WP_000911336.1 NZ_CP090545:961961-962359 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC
Download Length: 399 bp
>T231147 NZ_CP126085:278774-279124 [Peribacillus frigoritolerans]
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTTGGTTCAGAGCAGGGTGGGACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACACATGTTGAGATTAATGCAAAAAAGTACGGATTCGAGCGGGATTCCGTCATTTTATTAGAACAGATC
CGGACAATTGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAAAAAGTCAATGAAGCTTT
GCAAATTAGTCTAGGCCTCATTGAGTTTTAA
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTTGGTTCAGAGCAGGGTGGGACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACACATGTTGAGATTAATGCAAAAAAGTACGGATTCGAGCGGGATTCCGTCATTTTATTAGAACAGATC
CGGACAATTGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAAAAAGTCAATGAAGCTTT
GCAAATTAGTCTAGGCCTCATTGAGTTTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8514.51 Da Isoelectric Point: 5.0210
>AT231147 WP_000557549.1 NZ_CP090545:961734-961961 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF
Download Length: 228 bp
>AT231147 NZ_CP126085:278485-278766 [Peribacillus frigoritolerans]
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGATGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATTGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAGGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGATGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATTGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAGGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 6IFC | |
PDB | 6IFM |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V2Y5V5 |