Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4348004..4348629 Replicon chromosome
Accession NZ_CP085814
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Plusle

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF38_RS21180 Protein ID WP_000911336.1
Coordinates 4348004..4348402 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF38_RS21185 Protein ID WP_000557549.1
Coordinates 4348402..4348629 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF38_RS21165 (4344681) 4344681..4345262 - 582 WP_001244651.1 fimbrial protein -
LJF38_RS21170 (4345981) 4345981..4346613 - 633 WP_000835265.1 YfdX family protein -
LJF38_RS21175 (4346660) 4346660..4347196 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF38_RS21180 (4348004) 4348004..4348402 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF38_RS21185 (4348402) 4348402..4348629 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF38_RS21190 (4348838) 4348838..4349089 + 252 WP_001576352.1 hypothetical protein -
LJF38_RS21195 (4349369) 4349369..4350175 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF38_RS21205 (4350460) 4350460..4351218 - 759 WP_077946535.1 amidase activator ActS -
LJF38_RS21210 (4351483) 4351483..4352028 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF38_RS21215 (4352104) 4352104..4353621 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4339565..4350175 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221851 WP_000911336.1 NZ_CP085814:c4348402-4348004 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221851 NZ_CP117606:c4462470-4462318 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTATCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221851 WP_000557549.1 NZ_CP085814:c4348629-4348402 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221851 NZ_CP117606:4462519-4462576 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References