Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 4348004..4348629 | Replicon | chromosome |
Accession | NZ_CP085814 | ||
Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain Plusle |
Toxin (Protein)
Gene name | vapC | Uniprot ID | M7SD17 |
Locus tag | LJF38_RS21180 | Protein ID | WP_000911336.1 |
Coordinates | 4348004..4348402 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | M7S3S8 |
Locus tag | LJF38_RS21185 | Protein ID | WP_000557549.1 |
Coordinates | 4348402..4348629 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LJF38_RS21165 (4344681) | 4344681..4345262 | - | 582 | WP_001244651.1 | fimbrial protein | - |
LJF38_RS21170 (4345981) | 4345981..4346613 | - | 633 | WP_000835265.1 | YfdX family protein | - |
LJF38_RS21175 (4346660) | 4346660..4347196 | - | 537 | WP_001038502.1 | STM3031 family outer membrane protein | - |
LJF38_RS21180 (4348004) | 4348004..4348402 | - | 399 | WP_000911336.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
LJF38_RS21185 (4348402) | 4348402..4348629 | - | 228 | WP_000557549.1 | toxin-antitoxin system antitoxin VapB | Antitoxin |
LJF38_RS21190 (4348838) | 4348838..4349089 | + | 252 | WP_001576352.1 | hypothetical protein | - |
LJF38_RS21195 (4349369) | 4349369..4350175 | + | 807 | WP_001574939.1 | DUF1460 domain-containing protein | - |
LJF38_RS21205 (4350460) | 4350460..4351218 | - | 759 | WP_077946535.1 | amidase activator ActS | - |
LJF38_RS21210 (4351483) | 4351483..4352028 | + | 546 | WP_000133994.1 | isopentenyl-diphosphate Delta-isomerase | - |
LJF38_RS21215 (4352104) | 4352104..4353621 | - | 1518 | WP_000003339.1 | lysine--tRNA ligase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 4339565..4350175 | 10610 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14938.30 Da Isoelectric Point: 7.2155
>T221851 WP_000911336.1 NZ_CP085814:c4348402-4348004 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC
Download Length: 399 bp
>T221851 NZ_CP117606:c4462470-4462318 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTATCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
ATGAAGCAGCATAAGGCGATGATTATCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8514.51 Da Isoelectric Point: 5.0210
>AT221851 WP_000557549.1 NZ_CP085814:c4348629-4348402 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF
Download Length: 228 bp
>AT221851 NZ_CP117606:4462519-4462576 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 6IFC | |
PDB | 6IFM |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V2Y5V5 |