202931

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835237..835862 Replicon chromosome
Accession NZ_CP075113
Organism Salmonella enterica subsp. enterica serovar Dublin strain CFSAN059898

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag CCO47_RS04045 Protein ID WP_000911336.1
Coordinates 835464..835862 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag CCO47_RS04040 Protein ID WP_000557549.1
Coordinates 835237..835464 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO47_RS04010 (830245) 830245..831762 + 1518 WP_000003339.1 lysine--tRNA ligase -
CCO47_RS04015 (831838) 831838..832383 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
CCO47_RS04020 (832648) 832648..833406 + 759 WP_000244328.1 amidase activator ActS -
CCO47_RS04030 (833691) 833691..834497 - 807 WP_001574939.1 DUF1460 domain-containing protein -
CCO47_RS04035 (834777) 834777..835028 - 252 WP_001576352.1 hypothetical protein -
CCO47_RS04040 (835237) 835237..835464 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
CCO47_RS04045 (835464) 835464..835862 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
CCO47_RS04050 (836670) 836670..837206 + 537 WP_001038502.1 STM3031 family outer membrane protein -
CCO47_RS04055 (837253) 837253..837885 + 633 WP_000835265.1 YfdX family protein -
CCO47_RS04060 (838604) 838604..839185 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 833691..845052 11361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T202931 WP_000911336.1 NZ_CP075113:835464-835862 [Salmonella enterica subsp. enterica serovar Dublin]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T202931 NZ_CP099752:4288458-4288856 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT202931 WP_000557549.1 NZ_CP075113:835237-835464 [Salmonella enterica subsp. enterica serovar Dublin]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT202931 NZ_CP099752:4288231-4288458 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References