Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 370075..370700 Replicon chromosome
Accession NZ_CP085802
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailmer

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF51_RS01835 Protein ID WP_000911336.1
Coordinates 370302..370700 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF51_RS01830 Protein ID WP_000557549.1
Coordinates 370075..370302 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF51_RS01800 (365083) 365083..366600 + 1518 WP_000003339.1 lysine--tRNA ligase -
LJF51_RS01805 (366676) 366676..367221 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF51_RS01810 (367486) 367486..368244 + 759 WP_000244328.1 amidase activator ActS -
LJF51_RS01820 (368529) 368529..369335 - 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF51_RS01825 (369615) 369615..369866 - 252 WP_001576352.1 hypothetical protein -
LJF51_RS01830 (370075) 370075..370302 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF51_RS01835 (370302) 370302..370700 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF51_RS01840 (371508) 371508..372044 + 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF51_RS01845 (372091) 372091..372723 + 633 WP_000835265.1 YfdX family protein -
LJF51_RS01850 (373442) 373442..374023 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 368529..379884 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221565 WP_000911336.1 NZ_CP085802:370302-370700 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221565 NZ_CP117503:c2567691-2567590 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221565 WP_000557549.1 NZ_CP085802:370075-370302 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221565 NZ_CP117503:2567471-2567645 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References