Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835948..836573 Replicon chromosome
Accession NZ_CP120318
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain PS_Ent_2_2022

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag P1703_RS04030 Protein ID WP_000911336.1
Coordinates 836175..836573 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag P1703_RS04025 Protein ID WP_000557549.1
Coordinates 835948..836175 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1703_RS03995 (830956) 830956..832473 + 1518 WP_000003339.1 lysine--tRNA ligase -
P1703_RS04000 (832549) 832549..833094 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
P1703_RS04005 (833359) 833359..834117 + 759 WP_000244328.1 amidase activator ActS -
P1703_RS04015 (834402) 834402..835208 - 807 WP_001574939.1 DUF1460 domain-containing protein -
P1703_RS04020 (835488) 835488..835739 - 252 WP_001576352.1 hypothetical protein -
P1703_RS04025 (835948) 835948..836175 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
P1703_RS04030 (836175) 836175..836573 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
P1703_RS04035 (837381) 837381..837917 + 537 WP_001038502.1 STM3031 family outer membrane protein -
P1703_RS04040 (837964) 837964..838596 + 633 WP_000835265.1 YfdX family protein -
P1703_RS04045 (839315) 839315..839896 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 834402..845757 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T274625 WP_000911336.1 NZ_CP120318:836175-836573 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT274625 WP_000557549.1 NZ_CP120318:835948-836175 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References