Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835956..836581 Replicon chromosome
Accession NZ_CP097262
Organism Salmonella enterica subsp. enterica strain B3-6

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag M3N94_RS04025 Protein ID WP_000911336.1
Coordinates 836183..836581 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag M3N94_RS04020 Protein ID WP_000557549.1
Coordinates 835956..836183 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3N94_RS03990 (830964) 830964..832481 + 1518 WP_000003339.1 lysine--tRNA ligase -
M3N94_RS03995 (832557) 832557..833102 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
M3N94_RS04000 (833367) 833367..834125 + 759 WP_000244328.1 amidase activator ActS -
M3N94_RS04010 (834410) 834410..835216 - 807 WP_001574939.1 DUF1460 domain-containing protein -
M3N94_RS04015 (835496) 835496..835747 - 252 WP_001576352.1 hypothetical protein -
M3N94_RS04020 (835956) 835956..836183 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
M3N94_RS04025 (836183) 836183..836581 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
M3N94_RS04030 (837389) 837389..837925 + 537 WP_001038502.1 STM3031 family outer membrane protein -
M3N94_RS04035 (837972) 837972..838604 + 633 WP_000835265.1 YfdX family protein -
M3N94_RS04040 (839323) 839323..839904 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 834410..845765 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T245075 WP_000911336.1 NZ_CP097262:836183-836581 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT245075 WP_000557549.1 NZ_CP097262:835956-836183 [Salmonella enterica subsp. enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References