Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835942..836567 Replicon chromosome
Accession NZ_CP122301
Organism Salmonella enterica strain 27A

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag P8R57_RS04030 Protein ID WP_000911336.1
Coordinates 836169..836567 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag P8R57_RS04025 Protein ID WP_000557549.1
Coordinates 835942..836169 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R57_RS03995 (830950) 830950..832467 + 1518 WP_000003339.1 lysine--tRNA ligase -
P8R57_RS04000 (832543) 832543..833088 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
P8R57_RS04005 (833353) 833353..834111 + 759 WP_000244328.1 amidase activator ActS -
P8R57_RS04015 (834396) 834396..835202 - 807 WP_001574939.1 DUF1460 domain-containing protein -
P8R57_RS04020 (835482) 835482..835733 - 252 WP_001576352.1 hypothetical protein -
P8R57_RS04025 (835942) 835942..836169 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
P8R57_RS04030 (836169) 836169..836567 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
P8R57_RS04035 (837375) 837375..837911 + 537 WP_001038502.1 STM3031 family outer membrane protein -
P8R57_RS04040 (837958) 837958..838590 + 633 WP_000835265.1 YfdX family protein -
P8R57_RS04045 (839309) 839309..839890 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 834396..845751 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T276606 WP_000911336.1 NZ_CP122301:836169-836567 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT276606 WP_000557549.1 NZ_CP122301:835942-836169 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References