Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835748..836373 Replicon chromosome
Accession NZ_CP074661
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN008104

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag A9D71_RS04040 Protein ID WP_000911336.1
Coordinates 835975..836373 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag A9D71_RS04035 Protein ID WP_000557549.1
Coordinates 835748..835975 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D71_RS04005 (830756) 830756..832273 + 1518 WP_069057614.1 lysine--tRNA ligase -
A9D71_RS04010 (832349) 832349..832894 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
A9D71_RS04015 (833159) 833159..833917 + 759 WP_000244328.1 amidase activator ActS -
A9D71_RS04025 (834202) 834202..835008 - 807 WP_001574939.1 DUF1460 domain-containing protein -
A9D71_RS04030 (835288) 835288..835539 - 252 WP_001576352.1 hypothetical protein -
A9D71_RS04035 (835748) 835748..835975 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
A9D71_RS04040 (835975) 835975..836373 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
A9D71_RS04045 (837182) 837182..837718 + 537 WP_001038502.1 STM3031 family outer membrane protein -
A9D71_RS04050 (837765) 837765..838397 + 633 WP_000835265.1 YfdX family protein -
A9D71_RS04055 (839116) 839116..839697 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 834202..845552 11350


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T202541 WP_000911336.1 NZ_CP074661:835975-836373 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T202541 NZ_CP099497:c1716211-1716002 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT202541 WP_000557549.1 NZ_CP074661:835748-835975 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT202541 NZ_CP099497:c1716516-1716223 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References