Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 833419..834044 Replicon chromosome
Accession NZ_CP088136
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LRM91_RS04045 Protein ID WP_249895479.1
Coordinates 833646..834044 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LRM91_RS04040 Protein ID WP_000557549.1
Coordinates 833419..833646 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM91_RS04010 (828427) 828427..829944 + 1518 WP_000003339.1 lysine--tRNA ligase -
LRM91_RS04015 (830020) 830020..830565 - 546 WP_249895478.1 isopentenyl-diphosphate Delta-isomerase -
LRM91_RS04020 (830830) 830830..831588 + 759 WP_000244328.1 amidase activator ActS -
LRM91_RS04030 (831873) 831873..832679 - 807 WP_001574939.1 DUF1460 domain-containing protein -
LRM91_RS04035 (832959) 832959..833210 - 252 WP_001576352.1 hypothetical protein -
LRM91_RS04040 (833419) 833419..833646 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LRM91_RS04045 (833646) 833646..834044 + 399 WP_249895479.1 tRNA(fMet)-specific endonuclease VapC Toxin
LRM91_RS04050 (834853) 834853..835389 + 537 WP_249895480.1 STM3031 family outer membrane protein -
LRM91_RS04055 (835436) 835436..836068 + 633 WP_000835265.1 YfdX family protein -
LRM91_RS04060 (836787) 836787..837368 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 831873..843235 11362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14869.19 Da        Isoelectric Point: 6.7055

>T226767 WP_249895479.1 NZ_CP088136:833646-834044 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISSLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T226767 NZ_CP122624:20373-20624 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACCACGAAAATTACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT226767 WP_000557549.1 NZ_CP088136:833419-833646 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT226767 NZ_CP122624:20611-20838 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References