Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835947..836572 Replicon chromosome
Accession NZ_CP104641
Organism Salmonella enterica strain 1019942

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag N5927_RS04030 Protein ID WP_000911336.1
Coordinates 836174..836572 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag N5927_RS04025 Protein ID WP_000557549.1
Coordinates 835947..836174 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5927_RS03995 (830955) 830955..832472 + 1518 WP_000003339.1 lysine--tRNA ligase -
N5927_RS04000 (832548) 832548..833093 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
N5927_RS04005 (833358) 833358..834116 + 759 WP_000244328.1 amidase activator ActS -
N5927_RS04015 (834401) 834401..835207 - 807 WP_001574939.1 DUF1460 domain-containing protein -
N5927_RS04020 (835487) 835487..835738 - 252 WP_001576352.1 hypothetical protein -
N5927_RS04025 (835947) 835947..836174 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
N5927_RS04030 (836174) 836174..836572 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
N5927_RS04035 (837380) 837380..837916 + 537 WP_001038502.1 STM3031 family outer membrane protein -
N5927_RS04040 (837963) 837963..838595 + 633 WP_000835265.1 YfdX family protein -
N5927_RS04045 (839314) 839314..839895 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 834401..845756 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T258742 WP_000911336.1 NZ_CP104641:836174-836572 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT258742 WP_000557549.1 NZ_CP104641:835947-836174 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References