Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 835947..836572 | Replicon | chromosome |
Accession | NZ_CP104641 | ||
Organism | Salmonella enterica strain 1019942 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | M7SD17 |
Locus tag | N5927_RS04030 | Protein ID | WP_000911336.1 |
Coordinates | 836174..836572 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | M7S3S8 |
Locus tag | N5927_RS04025 | Protein ID | WP_000557549.1 |
Coordinates | 835947..836174 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N5927_RS03995 (830955) | 830955..832472 | + | 1518 | WP_000003339.1 | lysine--tRNA ligase | - |
N5927_RS04000 (832548) | 832548..833093 | - | 546 | WP_000133994.1 | isopentenyl-diphosphate Delta-isomerase | - |
N5927_RS04005 (833358) | 833358..834116 | + | 759 | WP_000244328.1 | amidase activator ActS | - |
N5927_RS04015 (834401) | 834401..835207 | - | 807 | WP_001574939.1 | DUF1460 domain-containing protein | - |
N5927_RS04020 (835487) | 835487..835738 | - | 252 | WP_001576352.1 | hypothetical protein | - |
N5927_RS04025 (835947) | 835947..836174 | + | 228 | WP_000557549.1 | toxin-antitoxin system antitoxin VapB | Antitoxin |
N5927_RS04030 (836174) | 836174..836572 | + | 399 | WP_000911336.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
N5927_RS04035 (837380) | 837380..837916 | + | 537 | WP_001038502.1 | STM3031 family outer membrane protein | - |
N5927_RS04040 (837963) | 837963..838595 | + | 633 | WP_000835265.1 | YfdX family protein | - |
N5927_RS04045 (839314) | 839314..839895 | + | 582 | WP_001244651.1 | fimbrial protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 834401..845756 | 11355 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14938.30 Da Isoelectric Point: 7.2155
>T258742 WP_000911336.1 NZ_CP104641:836174-836572 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC
Download Length: 399 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 6IFC | |
PDB | 6IFM |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V2Y5V5 |