221648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1144947..1145572 Replicon chromosome
Accession NZ_CP085805
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Azumarill

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF48_RS05510 Protein ID WP_000911336.1
Coordinates 1145174..1145572 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF48_RS05505 Protein ID WP_000557549.1
Coordinates 1144947..1145174 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF48_RS05475 (1139955) 1139955..1141472 + 1518 WP_000003339.1 lysine--tRNA ligase -
LJF48_RS05480 (1141548) 1141548..1142093 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF48_RS05485 (1142358) 1142358..1143116 + 759 WP_000244328.1 amidase activator ActS -
LJF48_RS05495 (1143401) 1143401..1144207 - 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF48_RS05500 (1144487) 1144487..1144738 - 252 WP_001576352.1 hypothetical protein -
LJF48_RS05505 (1144947) 1144947..1145174 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF48_RS05510 (1145174) 1145174..1145572 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF48_RS05515 (1146380) 1146380..1146916 + 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF48_RS05520 (1146963) 1146963..1147595 + 633 WP_000835265.1 YfdX family protein -
LJF48_RS05525 (1148314) 1148314..1148895 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1143401..1154756 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221648 WP_000911336.1 NZ_CP085805:1145174-1145572 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221648 NZ_CP117558:c4500097-4499723 [Escherichia albertii]
ATGGCAAAAAGAACTGCGCTTTTTGATACCAATATCCTTATTGATTTGTTCAGCGGACGAATTGAGGCAAAACAGGCACT
GGAGGCATGGCCCCTACAGAATGCGATTAGTCTGGTCACATGGATGGAGGTGCTGGCTGGCGCTAAAAAATACAATCAAG
AACATCGCATACGGATTGCAATGAGTGCGTTTAACGTTATTGGGATTTCGCAGGATATAGCGGAACGAAGCGTTGCTTTG
AGGCAAGAGTATAGAATGAAACTTCCAGATGCCATTATTCTGGCAACAGCACAGATTTATGGCTTTGAATTGGTAACGCG
AAATACGAGAGATTTTGCGGGAATAGCAGGTGTAATCACACCCTATCAACCGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221648 WP_000557549.1 NZ_CP085805:1144947-1145174 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221648 NZ_CP117558:c4500339-4500097 [Escherichia albertii]
ATGAGCGCTATGGCAGGTATGGATATGGGCAGAATTTTACTCGATTTATCCGATGAGGTGATTAAGCGACTTGATGATCT
CAAAGTGCAGCGCAATCTTCCTCGCGCAGAGCTATTACGAGAAGCGGTAGCTCAATATCTGGAAAATCAATCGAAAACGA
CAATATTCAGTGCTCTTGGTATCTGGCAAGGGTGTGAGGAAGATGGTGTCGAATATCAGCGTAAGCTGCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References