Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 477076..477701 Replicon chromosome
Accession NZ_CP060666
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag H9Q88_RS02415 Protein ID WP_000911336.1
Coordinates 477303..477701 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag H9Q88_RS02410 Protein ID WP_000557549.1
Coordinates 477076..477303 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q88_RS02380 (472084) 472084..473601 + 1518 WP_000003339.1 lysine--tRNA ligase -
H9Q88_RS02385 (473677) 473677..474222 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
H9Q88_RS02390 (474487) 474487..475245 + 759 WP_000244328.1 amidase activator ActS -
H9Q88_RS02400 (475530) 475530..476336 - 807 WP_001574939.1 DUF1460 domain-containing protein -
H9Q88_RS02405 (476616) 476616..476867 - 252 WP_001576352.1 hypothetical protein -
H9Q88_RS02410 (477076) 477076..477303 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9Q88_RS02415 (477303) 477303..477701 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
H9Q88_RS02420 (478509) 478509..479045 + 537 WP_001038502.1 STM3031 family outer membrane protein -
H9Q88_RS02425 (479092) 479092..479724 + 633 WP_000835265.1 YfdX family protein -
H9Q88_RS02430 (480443) 480443..481024 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 475530..486885 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T170539 WP_000911336.1 NZ_CP060666:477303-477701 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T170539 NZ_CP077425:999940-1000227 [Vibrio mimicus]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT170539 WP_000557549.1 NZ_CP060666:477076-477303 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT170539 NZ_CP077425:999662-999943 [Vibrio mimicus]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References