222053

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4350262..4350887 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF58_RS21210 Protein ID WP_000911336.1
Coordinates 4350489..4350887 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF58_RS21205 Protein ID WP_000557549.1
Coordinates 4350262..4350489 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS21175 (4345270) 4345270..4346787 + 1518 WP_000003339.1 lysine--tRNA ligase -
LJF58_RS21180 (4346863) 4346863..4347408 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF58_RS21185 (4347673) 4347673..4348431 + 759 WP_000244328.1 amidase activator ActS -
LJF58_RS21195 (4348716) 4348716..4349522 - 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF58_RS21200 (4349802) 4349802..4350053 - 252 WP_001576352.1 hypothetical protein -
LJF58_RS21205 (4350262) 4350262..4350489 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF58_RS21210 (4350489) 4350489..4350887 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF58_RS21215 (4351695) 4351695..4352231 + 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF58_RS21220 (4352278) 4352278..4352910 + 633 WP_000835265.1 YfdX family protein -
LJF58_RS21225 (4353629) 4353629..4354210 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4348716..4360071 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T222053 WP_000911336.1 NZ_CP085822:4350489-4350887 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T222053 NZ_CP117668:2810434-2810736 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGAATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAAGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT222053 WP_000557549.1 NZ_CP085822:4350262-4350489 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT222053 NZ_CP117668:2810808-2811146 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGACTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References