Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 872456..873081 Replicon chromosome
Accession NZ_CP117367
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM079

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag PQQ12_RS04270 Protein ID WP_000911336.1
Coordinates 872683..873081 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PQQ12_RS04265 Protein ID WP_000557549.1
Coordinates 872456..872683 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ12_RS04235 (867464) 867464..868981 + 1518 WP_000003339.1 lysine--tRNA ligase -
PQQ12_RS04240 (869057) 869057..869602 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PQQ12_RS04245 (869867) 869867..870625 + 759 WP_000244328.1 amidase activator ActS -
PQQ12_RS04255 (870910) 870910..871716 - 807 WP_001574939.1 DUF1460 domain-containing protein -
PQQ12_RS04260 (871996) 871996..872247 - 252 WP_001576352.1 hypothetical protein -
PQQ12_RS04265 (872456) 872456..872683 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQQ12_RS04270 (872683) 872683..873081 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQQ12_RS04275 (873890) 873890..874426 + 537 WP_001038502.1 STM3031 family outer membrane protein -
PQQ12_RS04280 (874473) 874473..875105 + 633 WP_000835265.1 YfdX family protein -
PQQ12_RS04285 (875824) 875824..876405 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 870910..882272 11362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T270847 WP_000911336.1 NZ_CP117367:872683-873081 [Salmonella enterica subsp. enterica serovar Dublin]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT270847 WP_000557549.1 NZ_CP117367:872456-872683 [Salmonella enterica subsp. enterica serovar Dublin]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References