Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1895729..1896354 Replicon chromosome
Accession NZ_CP085797
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF56_RS08955 Protein ID WP_000911336.1
Coordinates 1895956..1896354 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF56_RS08950 Protein ID WP_000557549.1
Coordinates 1895729..1895956 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF56_RS08920 (1890737) 1890737..1892254 + 1518 WP_000003339.1 lysine--tRNA ligase -
LJF56_RS08925 (1892330) 1892330..1892875 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF56_RS08930 (1893140) 1893140..1893898 + 759 WP_000244328.1 amidase activator ActS -
LJF56_RS08940 (1894183) 1894183..1894989 - 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF56_RS08945 (1895269) 1895269..1895520 - 252 WP_001576352.1 hypothetical protein -
LJF56_RS08950 (1895729) 1895729..1895956 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF56_RS08955 (1895956) 1895956..1896354 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF56_RS08960 (1897162) 1897162..1897698 + 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF56_RS08965 (1897745) 1897745..1898377 + 633 WP_000835265.1 YfdX family protein -
LJF56_RS08970 (1899096) 1899096..1899677 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1894183..1905538 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221444 WP_000911336.1 NZ_CP085797:1895956-1896354 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221444 NZ_CP117394:1901171-1901524 [Salmonella enterica subsp. enterica serovar Uganda]
GTGTGGACAATTAAAACAACGGATACGTTTGATCGCTGGTTTGCCTCGCTCAACGATACCAACAGGGTCAGCGTGCTTGC
AGCACTGCTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGGTCAGAGGTTCCCGTTACAGCA
ACATGAAAGAGCTACGTATTCAGAGTCGGGGCGAGCCGATACGGGCGTTTTTCGCTTTTGACCCGACCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAGGTCGGTAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGACAGGGAATTCAC
GAACTGGCTGAACACATTAAAAGAGAAGGAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221444 WP_000557549.1 NZ_CP085797:1895729-1895956 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221444 NZ_CP117394:1901529-1901831 [Salmonella enterica subsp. enterica serovar Uganda]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAGAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGTGAGAAAGTACAGAAAACGCAGGTGGAGATGGCACAGGCGCTGGGCATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCAGGGCGCGATCTGAAGCTTTCCACTCTCAAACGCTACGTTGAAGCGACA
GGCGGCAAGCTACGTCTTGATGTTGAACTGCCGGATGGTTCTCACTACGGATTTGTACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References