Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2458151..2458776 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NED09_RS11810 Protein ID WP_000911336.1
Coordinates 2458378..2458776 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NED09_RS11805 Protein ID WP_000557549.1
Coordinates 2458151..2458378 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS11775 (2453159) 2453159..2454676 + 1518 WP_000003339.1 lysine--tRNA ligase -
NED09_RS11780 (2454752) 2454752..2455297 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NED09_RS11785 (2455562) 2455562..2456320 + 759 WP_000244328.1 amidase activator ActS -
NED09_RS11795 (2456605) 2456605..2457411 - 807 WP_001574939.1 DUF1460 domain-containing protein -
NED09_RS11800 (2457691) 2457691..2457942 - 252 WP_001576352.1 hypothetical protein -
NED09_RS11805 (2458151) 2458151..2458378 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NED09_RS11810 (2458378) 2458378..2458776 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NED09_RS11815 (2459584) 2459584..2460120 + 537 WP_001038502.1 STM3031 family outer membrane protein -
NED09_RS11820 (2460167) 2460167..2460799 + 633 WP_000835265.1 YfdX family protein -
NED09_RS11825 (2461518) 2461518..2462099 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2456605..2467960 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T282713 WP_000911336.1 NZ_CP126166:2458378-2458776 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT282713 WP_000557549.1 NZ_CP126166:2458151-2458378 [Salmonella enterica subsp. enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References