Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1182612..1183237 Replicon chromosome
Accession NZ_CP060668
Organism Salmonella enterica strain 190819_2

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag H9Q87_RS05705 Protein ID WP_000911336.1
Coordinates 1182839..1183237 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag H9Q87_RS05700 Protein ID WP_000557549.1
Coordinates 1182612..1182839 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q87_RS05670 (1177620) 1177620..1179137 + 1518 WP_000003339.1 lysine--tRNA ligase -
H9Q87_RS05675 (1179213) 1179213..1179758 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
H9Q87_RS05680 (1180023) 1180023..1180781 + 759 WP_000244328.1 amidase activator ActS -
H9Q87_RS05690 (1181066) 1181066..1181872 - 807 WP_001574939.1 DUF1460 domain-containing protein -
H9Q87_RS05695 (1182152) 1182152..1182403 - 252 WP_001576352.1 hypothetical protein -
H9Q87_RS05700 (1182612) 1182612..1182839 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9Q87_RS05705 (1182839) 1182839..1183237 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
H9Q87_RS05710 (1184045) 1184045..1184581 + 537 WP_001038502.1 STM3031 family outer membrane protein -
H9Q87_RS05715 (1184628) 1184628..1185260 + 633 WP_000835265.1 YfdX family protein -
H9Q87_RS05720 (1185979) 1185979..1186560 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1181066..1192421 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T170571 WP_000911336.1 NZ_CP060668:1182839-1183237 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T170571 NZ_CP077646:3387532-3387939 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT170571 WP_000557549.1 NZ_CP060668:1182612-1182839 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT170571 NZ_CP077646:3387285-3387551 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References