Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3766669..3767294 Replicon chromosome
Accession NZ_CP060676
Organism Salmonella enterica strain 190704_2

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag H9Q83_RS18600 Protein ID WP_000911336.1
Coordinates 3766896..3767294 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag H9Q83_RS18595 Protein ID WP_000557549.1
Coordinates 3766669..3766896 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q83_RS18565 (3761677) 3761677..3763194 + 1518 WP_000003339.1 lysine--tRNA ligase -
H9Q83_RS18570 (3763270) 3763270..3763815 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
H9Q83_RS18575 (3764080) 3764080..3764838 + 759 WP_000244328.1 amidase activator ActS -
H9Q83_RS18585 (3765123) 3765123..3765929 - 807 WP_001574939.1 DUF1460 domain-containing protein -
H9Q83_RS18590 (3766209) 3766209..3766460 - 252 WP_001576352.1 hypothetical protein -
H9Q83_RS18595 (3766669) 3766669..3766896 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9Q83_RS18600 (3766896) 3766896..3767294 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
H9Q83_RS18605 (3768102) 3768102..3768638 + 537 WP_001038502.1 STM3031 family outer membrane protein -
H9Q83_RS18610 (3768685) 3768685..3769317 + 633 WP_000835265.1 YfdX family protein -
H9Q83_RS18615 (3770036) 3770036..3770617 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3765123..3776478 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T170701 WP_000911336.1 NZ_CP060676:3766896-3767294 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T170701 NZ_CP077680:239398-239709 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT170701 WP_000557549.1 NZ_CP060676:3766669-3766896 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT170701 NZ_CP077680:239710-240000 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTAAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGCTCACCGACAGGGCCAGCCAAAGCATTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References