Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4382561..4383186 Replicon chromosome
Accession NZ_CP085799
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Swellow

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF54_RS21460 Protein ID WP_000911336.1
Coordinates 4382788..4383186 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF54_RS21455 Protein ID WP_000557549.1
Coordinates 4382561..4382788 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF54_RS21425 (4377569) 4377569..4379086 + 1518 WP_000003339.1 lysine--tRNA ligase -
LJF54_RS21430 (4379162) 4379162..4379707 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF54_RS21435 (4379972) 4379972..4380730 + 759 WP_000244328.1 amidase activator ActS -
LJF54_RS21445 (4381015) 4381015..4381821 - 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF54_RS21450 (4382101) 4382101..4382352 - 252 WP_001576352.1 hypothetical protein -
LJF54_RS21455 (4382561) 4382561..4382788 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF54_RS21460 (4382788) 4382788..4383186 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF54_RS21465 (4383994) 4383994..4384530 + 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF54_RS21470 (4384577) 4384577..4385209 + 633 WP_000835265.1 YfdX family protein -
LJF54_RS21475 (4385928) 4385928..4386509 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4381015..4392370 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221510 WP_000911336.1 NZ_CP085799:4382788-4383186 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221510 NZ_CP117402:c3990039-3989755 [Salmonella enterica subsp. enterica serovar Give]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCTGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221510 WP_000557549.1 NZ_CP085799:4382561-4382788 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221510 NZ_CP117402:c3990271-3990029 [Salmonella enterica subsp. enterica serovar Give]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References