215578

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3101078..3101703 Replicon chromosome
Accession NZ_CP082916
Organism Salmonella enterica subsp. enterica serovar Newlands strain ZC-S1 3rd

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag K8862_RS15050 Protein ID WP_000911336.1
Coordinates 3101305..3101703 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag K8862_RS15045 Protein ID WP_000557549.1
Coordinates 3101078..3101305 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8862_RS15015 (3096086) 3096086..3097603 + 1518 WP_000003339.1 lysine--tRNA ligase -
K8862_RS15020 (3097679) 3097679..3098224 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
K8862_RS15025 (3098489) 3098489..3099247 + 759 WP_000244328.1 amidase activator ActS -
K8862_RS15035 (3099532) 3099532..3100338 - 807 WP_001574939.1 DUF1460 domain-containing protein -
K8862_RS15040 (3100618) 3100618..3100869 - 252 WP_001576352.1 hypothetical protein -
K8862_RS15045 (3101078) 3101078..3101305 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
K8862_RS15050 (3101305) 3101305..3101703 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
K8862_RS15055 (3102511) 3102511..3103047 + 537 WP_001038502.1 STM3031 family outer membrane protein -
K8862_RS15060 (3103094) 3103094..3103726 + 633 WP_000835265.1 YfdX family protein -
K8862_RS15065 (3104445) 3104445..3105026 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3099532..3110887 11355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T215578 WP_000911336.1 NZ_CP082916:3101305-3101703 [Salmonella enterica subsp. enterica serovar Newlands]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T215578 NZ_CP110816:1956253-1956356 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT215578 WP_000557549.1 NZ_CP082916:3101078-3101305 [Salmonella enterica subsp. enterica serovar Newlands]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT215578 NZ_CP110816:c1956394-1956123 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References