26042

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) IasE-IsrA/-
Location 340013..340445 Replicon
Accession NC_016856
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag STM14_RS02070 Protein ID WP_000994224.1
Coordinates 340013..340288 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 340023..340445 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STM14_RS02050 337324..337587 + 264 WP_000932531.1 hypothetical protein -
STM14_RS02055 (STM14_0341) 337651..338520 + 870 Protein_289 polymorphic toxin type 47 domain-containing protein -
STM14_RS02060 (STM14_0342) 338514..338960 + 447 WP_000935097.1 protein SciX -
STM14_RS02065 (STM14_0345) 339523..339960 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
STM14_RS02070 (STM14_0346) 340013..340288 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 340023..340445 + 423 - - Antitoxin
STM14_RS26695 340473..340646 + 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
STM14_RS02075 (STM14_0348) 340729..341037 + 309 WP_010988969.1 hypothetical protein -
STM14_RS24395 (STM14_0349) 341139..341387 - 249 WP_001738030.1 SymE family type I addiction module toxin -
STM14_RS25855 341440..342144 + 705 Protein_296 integrase core domain-containing protein -
STM14_RS02095 (STM14_0352) 342894..343406 + 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
STM14_RS02100 (STM14_0353) 343490..344227 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 337747..352035 14288
flank IS/Tn - - 341863..342144 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-57)


Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T26042 WP_000994224.1 NC_016856:c340288-340013 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T26042 NC_016856:c340288-340013 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT26042 NC_016856:340023-340445 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5


Antitoxin

Download structure file

References