Detailed information of TA system TA233639

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3785709..3786141
• Replicon: chromosome
• Accession: NZ_CP091544
• Organism: Salmonella enterica strain 1618

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: L4414_RS18785
• Protein ID: WP_000994224.1
• Coordinates: 3785866..3786141 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3785709..3786131 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4414_RS18755	3781927..3782664	-	738	WP_001535430.1	pili assembly chaperone SafB	-
L4414_RS18760	3782748..3783260	-	513	WP_077248260.1	pilus assembly protein	-
L4414_RS18765	3784010..3784714	-	705	Protein_3679	integrase core domain-containing protein	-
L4414_RS18770	3784767..3785015	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
L4414_RS18775	3785117..3785425	-	309	WP_010988969.1	hypothetical protein	-
L4414_RS18780	3785508..3785624	-	117	WP_227457392.1	hypothetical protein	-
-	3785709..3786131	-	423	-	-	Antitoxin
L4414_RS18785	3785866..3786141	+	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
L4414_RS18790	3786194..3786631	-	438	WP_000943619.1	immunity 26/phosphotriesterase HocA family protein	-
L4414_RS18795	3787194..3787640	-	447	WP_000935097.1	protein SciX	-
L4414_RS18800	3787634..3788503	-	870	Protein_3686	polymorphic toxin type 47 domain-containing protein	-
L4414_RS18805	3788567..3788830	-	264	WP_000932531.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003197 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 IS/Tn TA010105 341179..341460 0 View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA010103 340656..340937 0 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026042 341863..342144 0	flank	IS/Tn	-	-	3784010..3784291	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T233639 WP_000994224.1 NZ_CP091544:3785866-3786141 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

>T233639 NZ_JMSI01000003:373697-374080 [Lacticaseibacillus rhamnosus 51B]
ATGGATGTAACAGTCAAACGCGGGGATGTATTTTTCGCCGATTTATCGCCGGTTGTCGGGTCGGAACAAGGCGGCAACCG
GCCCGTACTTATTATTCAAAACAATGTTGGTAACCATTATAGCCCCACTGTTATCGTGGCTGCCATTACCTCCAAAATCC
AAAAACCCAAAATGCCCACCCATGTCGGTTTGCGCGCCAAGCAAGACGGGGTTGAGCGTAATTCAGTCATTTTGCTTGAA
CAGATTCGTACAATTGATAAGCAACGGTTACAGGCACGCGTTACCGCTCTTTCAAGTGCCAAAATGGCAGCGGTGGATCG
GGCACTGGCGATATCGGTCGGACTCGTCAGCTTGCCTAAGCCGAAAACATATAATAAAAACTAA

Antitoxin

Nucleotide

• Length: 423 bp

>AT233639 NZ_CP091544:c3786131-3785709 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin