10103

Detailed information of TA system    

experimentalExperimentally validated    

Overview


TA module


Type I Classification (family/domain) IasE-IsrA/-
Location 338806..339238 Replicon
Accession NC_016810
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)


Gene name IasE Uniprot ID -
Locus tag - Protein ID -
Coordinates 338806..339081 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 338816..339238 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SL1344_RS01480 (SL1344_0286A) 336117..336380 + 264 WP_000932531.1 hypothetical protein -
SL1344_RS01485 (SL1344_0286B) 336444..337313 + 870 Protein_288 polymorphic toxin type 47 domain-containing protein -
SL1344_RS01490 (SL1344_0288) 337307..337753 + 447 WP_000935097.1 protein SciX -
SL1344_RS01495 (SL1344_0289) 338316..338753 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
SL1344_RS01500 338806..339081 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 338816..339238 + 423 - - Antitoxin
SL1344_RS27605 339266..339439 + 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
SL1344_RS01505 (SL1344_0291) 339522..339830 + 309 WP_010988969.1 hypothetical protein -
SL1344_RS24945 (SL1344_0292) 339932..340180 - 249 WP_001738030.1 SymE family type I addiction module toxin -
SL1344_RS26520 (SL1344_0294) 340233..340937 + 705 Protein_295 integrase core domain-containing protein -
SL1344_RS01525 (SL1344_0295) 341687..342199 + 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
SL1344_RS01530 (SL1344_0296) 342283..343020 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 336540..350828 14288
flank IS/Tn - - 340656..340937 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-57)


Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T10103 - NC_016810:c339081-338806 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T10103 NC_016810:c339081-338806 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT10103 NC_016810:338816-339238 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
T6351 Escherichia coli BW2952

49.123

62.637

0.308

T6352 Escherichia coli str. K-12 substr. MG1655

49.123

62.637

0.308


Multiple sequence alignment    


Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References


(1) Lillian G Acuña et al. (2020) The cis-encoded antisense RNA IsrA from Salmonella Typhimurium represses the expression of STM0294.1n (iasE), an SOS-induced gene coding for an endoribonuclease activity. Biochemical And Biophysical Research Communications 526(3):706-712. [PubMed:32253028] experimental


experimental experimental literature