201388

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 339385..339817 Replicon chromosome
Accession NZ_CP074094
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain A_cip

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag KFU99_RS01495 Protein ID WP_000994224.1
Coordinates 339385..339660 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 339395..339817 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU99_RS01475 336696..336959 + 264 WP_000932531.1 hypothetical protein -
KFU99_RS01480 337023..337892 + 870 Protein_288 polymorphic toxin type 47 domain-containing protein -
KFU99_RS01485 337886..338332 + 447 WP_000935097.1 protein SciX -
KFU99_RS01490 338895..339332 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
KFU99_RS01495 339385..339660 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 339395..339817 + 423 - - Antitoxin
KFU99_RS24030 339845..340018 + 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
KFU99_RS01505 340101..340379 + 279 WP_077917538.1 hypothetical protein -
KFU99_RS01510 340511..340759 - 249 Protein_294 SymE family type I addiction module toxin -
KFU99_RS01515 340812..341516 + 705 Protein_295 integrase core domain-containing protein -
KFU99_RS01520 342266..342778 + 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
KFU99_RS01525 342862..343599 + 738 WP_212634574.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 337119..351407 14288
- flank IS/Tn - - 341235..341516 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T201388 WP_000994224.1 NZ_CP074094:c339660-339385 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T201388 NZ_CP098350:2074652-2074754 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 423 bp

>AT201388 NZ_CP074094:339395-339817 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References