251313

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3637435..3637867 Replicon chromosome
Accession NZ_CP100739
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0292

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NL736_RS17870 Protein ID WP_000994224.1
Coordinates 3637592..3637867 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3637435..3637857 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL736_RS17840 3633653..3634390 - 738 WP_001535430.1 pili assembly chaperone SafB -
NL736_RS17845 3634474..3634986 - 513 WP_077248260.1 pilus assembly protein -
NL736_RS17850 3635736..3636440 - 705 Protein_3488 integrase core domain-containing protein -
NL736_RS17855 3636493..3636741 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NL736_RS17860 3636843..3637151 - 309 WP_010988969.1 hypothetical protein -
NL736_RS17865 3637234..3637350 - 117 WP_227457392.1 hypothetical protein -
- 3637435..3637857 - 423 - - Antitoxin
NL736_RS17870 3637592..3637867 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NL736_RS17875 3637920..3638357 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NL736_RS17880 3638920..3639366 - 447 WP_000935097.1 protein SciX -
NL736_RS17885 3639360..3640229 - 870 Protein_3495 polymorphic toxin type 47 domain-containing protein -
NL736_RS17890 3640293..3640556 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3628907..3640556 11649
flank IS/Tn - - 3635736..3636017 281
inside Genomic island - - 3626583..3640556 13973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T251313 WP_000994224.1 NZ_CP100739:3637592-3637867 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT251313 NZ_CP100739:c3637857-3637435 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References