Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) Rhs/-
Location 332552..337836 Replicon chromosome
Accession NC_003197
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Toxin (Protein)


Gene name Rhs Uniprot ID -
Locus tag STM0291 Protein ID NP_459289.1
Coordinates 332552..336646 (+) Length 1365 a.a.

Antitoxin (Protein)


Gene name RhsI Uniprot ID -
Locus tag STM0292 Protein ID NP_459290.1
Coordinates 337096..337836 (+) Length 247 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STM0286 327731..328519 + 789 NP_459284.1 putative cytoplasmic protein -
STM0287 328516..328932 + 417 NP_459285.1 putative periplasmic protein -
STM0288 328956..329477 + 522 NP_459286.1 putative cytoplasmic protein -
STM0289 329874..332063 + 2190 NP_459287.1 putative cytoplasmic protein -
STM0290 332087..332533 + 447 NP_459288.1 putative cytoplasmic protein -
STM0291 332552..336646 + 4095 NP_459289.1 putative RHS-family protein Toxin
STM0292 337096..337836 + 741 NP_459290.1 putative RHS-family protein Antitoxin
STM0293 337830..338276 + 447 NP_459291.1 putative cytoplasmic protein -
STM0294 338839..339276 + 438 NP_459292.1 putative cytoplasmic protein -
STM0295 340045..340353 + 309 NP_459293.1 putative cytoplasmic protein -
STM0296 340455..340703 - 249 NP_446753.1 putative cytoplasmic protein -
STM0297 340756..340953 + 198 NP_446754.1 putative transposase -
STM0298 341179..341460 + 282 NP_446755.1 putative integrase core domain protein -
STM0299 342210..342722 + 513 NP_459297.1 putative outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 341179..341460 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF6531

(224-296)

Antitoxin

Bacterial toxin 47

(122-236)


Sequences

Toxin        


Download         Length: 1365 a.a.        Molecular weight: 152023.37 Da        Isoelectric Point: 6.0353

>T10105 NP_459289.1 NC_003197:332552-336646 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MYEAARVDDPIYHTSALAGFLIGAIIGIAIIALAAFAFFSCGFLAGLILGFMADQIASGVLQLGEAIGRSIHHTAGKILT
GSENVSTNSRPAARAVLSTVKCDNHIAEKRIAQGSENIYINSQPAARKDDHTECDAVIEDGSPNVFLGGGTQTVLEISSE
IPDWLRKVVDVLFVVASLLGGLAGAWRQAAKLGTKFGTKCAAKFIGGELVGMAVGEAISGLFSNPVDVTTGQKILLPETD
FTLPGRLPVTCSRFYASHLETVGLLGRGWRLNWETSLRDDDEHITLTGVQGRELRYPKTMLTPGHQIFDPEEQLYLSRLH
DGRYVLHYTDRSYYVFGDFDSDGMAYLLFMETPHRQRIVFGHEGGRLVRIASSSGHHLLLHRTQTPAGERLSRIELVQGG
TRGNLVEYRYDDNGQLTGVVNRAGTQVRQFAYENGLMTAHSNATGFTCRYRWQELDGAPRVTEHDTSDGEHYRFDYDFAA
GTTTVTGRQGETWQWWYDRETYITAHRTPGGGMYRFTYNEDHFPVNIELPGGRTVAYEYDIQNRVVKTTDPEGRVTQTQW
NGEFDEITRTALDDDAVWKTQYNAHGQPVQETDPEGRVTQYAYDEQGQMCSRTDAAGGTVVTAFDSRGQMTRYTDCSGRS
TGYDHDEDGNLTRVTDAEGKVVRISYNRLGLPETVNSPGKQQDRYTWNALGLMSSHRRITGSVESWRYTPRGLLAAHTDE
EKRETRWQYTPEGRVAALTNGNGAQYRFSHDADGRLVREVRPDGLSRTFILDDSGYLTAIQTTGTQGGVRRETQQRDALG
RLLRTENEHGQRTFSYNRLDQITAVTLTPTEAGQQQHRMQADTVRFEYDRSGWLTAEHAGNGSICYQRDALGNPTDITLP
DGQHLTHLYYGSGHLLQTALDGLTVSEYERDSLHRQIMRTQGQLATYSGYDDDGLLSWQRSLASGSAPVLPGQRPARQGC
VTSRDYYWNNHGEVGTIDDGLRGSVVYSYDRSGYLTGRSGQMYDHDRYYYDKAGNLLDNEGQGAVMSNRLPGCGRDRYGY
NEWGELTTRRDQQLEWNAQGQLTRVISGNTETHYGYDALGRRTRKATYGRHTGHTARSRTDFVWEGFRLLQENVQQQGWR
TYLYDAEQPYTPVASVTGRGESRQVWYYHTDVTGTPQEVTAADGTLVWAGYIRGFGENAADISNSGAYFHQPLRLPGQYF
DDETGLHYNLFRYYAPECGRFVSQDPIGLRGGLNLYQYAPNPLKYIDPLGLTATVGRWMGPAEYQQMLDTGTVVQSSTGT
THVAYPADIDAFGKQAKNGAMYVEFDVPEKSLVPTNEGWAKIVGPDSIEGRLAKRKGLPVPEMPTAENITVRGEKINGEV
EAKC

Download         Length: 4095 bp

>T10105 NC_003197:332552-336646 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGTATGAAGCAGCCCGTGTGGATGATCCTATCTACCACACCAGCGCGCTCGCCGGGTTTCTTATCGGCGCTATCATCGG
CATCGCCATTATCGCGCTTGCCGCCTTTGCCTTCTTTAGCTGCGGTTTTCTTGCCGGGCTGATTCTGGGTTTTATGGCCG
ATCAAATAGCCTCCGGGGTATTGCAACTGGGCGAGGCCATCGGGCGCTCCATCCACCACACGGCAGGAAAAATCCTCACC
GGTTCGGAGAATGTCAGCACCAACAGTCGCCCGGCGGCGCGCGCGGTACTGAGTACGGTGAAATGCGATAACCATATCGC
AGAAAAACGCATCGCCCAAGGGTCGGAAAATATCTACATCAACAGCCAGCCCGCCGCCCGTAAGGATGACCACACCGAAT
GCGACGCGGTGATTGAAGACGGTTCGCCGAATGTGTTTCTCGGCGGCGGCACACAGACGGTACTGGAAATCAGTTCTGAA
ATTCCGGACTGGCTGCGCAAGGTGGTGGATGTATTGTTTGTCGTGGCGAGTCTGCTCGGCGGGCTGGCCGGGGCGTGGCG
GCAGGCGGCAAAGCTGGGGACGAAATTTGGCACTAAATGTGCCGCTAAGTTTATCGGCGGGGAGCTTGTCGGGATGGCCG
TGGGTGAGGCTATCAGCGGGCTGTTCAGCAATCCGGTGGATGTGACCACCGGGCAGAAAATCCTGCTGCCGGAAACGGAC
TTCACCCTGCCCGGTCGCCTGCCGGTCACCTGCTCGCGTTTTTACGCCAGCCACCTGGAAACTGTGGGACTGTTGGGACG
GGGCTGGCGGCTGAACTGGGAAACCAGCCTGCGCGATGACGATGAACACATCACGCTGACCGGCGTACAGGGGCGGGAAC
TGCGTTACCCGAAAACGATGCTGACGCCCGGCCACCAGATATTTGACCCGGAAGAACAGTTATACCTCAGCCGCCTGCAT
GACGGGCGTTACGTGCTGCATTACACCGATCGCAGCTATTACGTATTTGGTGATTTTGACAGTGACGGCATGGCATACCT
GCTGTTTATGGAGACGCCGCACCGCCAGCGCATTGTCTTCGGGCACGAAGGAGGCAGACTGGTACGGATAGCCTCCAGCA
GCGGGCATCACCTGTTACTGCACCGCACACAGACCCCGGCAGGGGAGCGGCTGTCGCGAATTGAACTGGTGCAGGGCGGC
ACCCGTGGCAATCTGGTGGAGTACCGGTATGACGATAACGGTCAACTGACCGGCGTGGTGAACCGGGCGGGAACGCAGGT
GCGTCAGTTTGCTTATGAAAACGGGCTGATGACGGCGCACAGCAATGCGACGGGGTTCACCTGCCGCTACCGCTGGCAGG
AACTCGACGGCGCGCCGCGCGTGACGGAGCACGACACCAGTGACGGCGAACATTACCGCTTTGACTATGATTTTGCCGCA
GGCACCACCACCGTCACCGGCAGGCAGGGGGAGACATGGCAGTGGTGGTACGACAGGGAAACGTATATCACCGCGCACCG
GACGCCGGGCGGTGGAATGTACCGCTTCACGTACAACGAAGACCACTTCCCTGTCAACATTGAGCTGCCCGGCGGTCGCA
CGGTGGCGTATGAATATGACATCCAGAACCGGGTGGTGAAGACGACAGATCCGGAAGGCCGGGTGACGCAGACGCAGTGG
AACGGCGAGTTCGACGAAATCACGCGCACGGCGCTGGACGATGACGCTGTCTGGAAAACGCAGTACAACGCCCACGGCCA
GCCAGTGCAGGAGACGGACCCGGAAGGGCGGGTGACGCAGTACGCTTACGATGAACAGGGGCAGATGTGCAGCCGGACGG
ATGCGGCGGGCGGCACGGTGGTGACGGCGTTCGACAGCCGGGGGCAGATGACGCGGTACACCGACTGTTCAGGGCGCAGC
ACAGGATATGACCACGATGAGGACGGCAACCTGACGCGGGTGACGGACGCGGAAGGGAAGGTGGTACGCATCAGCTACAA
CCGACTTGGGTTGCCGGAGACGGTAAACTCACCGGGGAAACAGCAGGACAGGTATACCTGGAATGCGCTGGGGCTGATGA
GCAGCCACCGGCGCATCACGGGGAGCGTGGAGAGCTGGCGGTATACGCCGCGCGGTCTGCTGGCGGCGCACACGGATGAG
GAGAAGCGCGAGACGCGCTGGCAGTACACGCCGGAAGGCCGGGTGGCAGCGCTGACCAACGGCAACGGGGCGCAGTACCG
GTTCAGTCACGATGCGGACGGCAGGCTGGTGCGTGAGGTTCGCCCGGACGGACTGAGCCGTACTTTTATCCTGGACGACA
GCGGTTATCTGACGGCGATACAGACCACGGGCACGCAGGGCGGCGTGCGGCGGGAGACGCAGCAGCGGGATGCGCTGGGC
CGTCTGTTACGGACGGAGAATGAACACGGCCAGCGGACGTTCAGCTACAACCGGCTGGACCAGATAACGGCAGTGACGCT
CACGCCCACGGAGGCGGGGCAACAGCAGCACCGGATGCAGGCCGACACGGTGCGTTTTGAGTATGACCGCAGCGGCTGGC
TGACGGCGGAGCACGCGGGGAACGGTAGCATATGTTATCAGCGCGACGCGCTGGGCAACCCGACGGACATCACGCTGCCG
GACGGGCAGCACCTGACGCATCTGTATTACGGGAGCGGGCATCTGTTACAGACGGCGCTGGACGGCCTGACGGTGAGCGA
GTATGAGCGCGACAGCCTGCACCGTCAGATAATGCGCACGCAGGGGCAGCTTGCGACGTACAGCGGCTATGACGACGACG
GGCTGCTGAGCTGGCAGCGCAGTCTGGCGTCCGGCAGTGCCCCTGTTCTTCCTGGCCAGCGCCCGGCGCGGCAGGGCTGC
GTGACGTCGAGGGACTATTACTGGAACAACCACGGCGAGGTGGGCACGATTGACGACGGCCTGCGTGGCAGCGTGGTGTA
CAGCTATGACAGAAGCGGTTACCTGACCGGGCGCTCAGGTCAGATGTATGACCATGACCGTTATTATTACGATAAGGCGG
GCAACCTGCTGGATAACGAAGGGCAGGGAGCGGTGATGAGCAACCGGCTGCCGGGCTGTGGTCGTGACCGTTACGGCTAT
AACGAGTGGGGCGAGCTGACCACGCGGCGCGACCAGCAACTGGAGTGGAACGCGCAGGGGCAGCTGACGCGGGTCATCAG
CGGCAACACGGAGACGCACTACGGCTACGATGCGCTGGGGAGGCGAACCCGCAAGGCGACGTACGGGCGGCACACGGGCC
ATACGGCGCGGAGCCGGACGGACTTTGTGTGGGAGGGGTTCAGGCTGTTGCAGGAGAACGTGCAGCAGCAGGGCTGGCGG
ACCTATCTGTACGATGCGGAACAGCCGTACACGCCGGTGGCGAGCGTGACGGGGCGGGGAGAAAGCAGGCAGGTGTGGTA
TTACCACACGGATGTGACGGGCACGCCGCAGGAGGTGACGGCGGCGGACGGAACGCTGGTGTGGGCGGGGTATATCAGGG
GGTTTGGAGAGAATGCGGCGGACATCAGCAACAGCGGGGCGTACTTTCACCAGCCGCTGCGGCTGCCGGGGCAGTATTTT
GACGACGAGACAGGGCTGCATTACAATCTGTTCAGATATTATGCACCGGAGTGTGGACGGTTTGTCAGTCAGGATCCGAT
CGGGCTGAGGGGCGGGTTAAACCTTTATCAGTATGCGCCAAATCCTCTCAAATATATAGACCCACTTGGTTTAACCGCGA
CTGTTGGGCGATGGATGGGGCCTGCGGAATATCAGCAAATGCTTGATACTGGGACAGTAGTACAAAGTTCAACAGGGACA
ACTCATGTTGCCTACCCTGCTGATATAGATGCTTTTGGTAAGCAAGCAAAAAATGGTGCTATGTATGTTGAATTTGATGT
GCCTGAAAAATCATTAGTACCTACAAATGAAGGATGGGCAAAAATAGTAGGGCCAGATTCTATCGAAGGGCGATTAGCTA
AACGCAAAGGTTTGCCTGTTCCTGAAATGCCAACAGCAGAAAACATAACTGTAAGGGGCGAGAAAATTAATGGGGAAGTT
GAAGCAAAATGCTAA

Antitoxin


Download         Length: 247 a.a.        Molecular weight: 26961.56 Da        Isoelectric Point: 5.7786

>AT10105 NP_459290.1 NC_003197:337096-337836 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
VQQQGWRTYLYDAEQPYTPVASVTGKGESRQVWYYHTDVTGTPQEVTAADGTLVWAGYIKGFGENAADISNSGAYFHQPL
RLPGQYFDDETGLHYNLFRYYAPECGRFVSQDPIGLAGGLNLYQYAPNPIRWIDPLGLAILEHQSNFDAARRTGFENAGM
TNPEDVTFSKVDPKTGTVVEFKGPNGAKVAYDAPHADMDVTAGHDKPHVGWQSAGKRGSGGANRGNITYDGPQHPHRSDS
KGDDKC

Download         Length: 741 bp

>AT10105 NC_003197:337096-337836 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
GTGCAGCAGCAGGGCTGGCGGACATATCTGTACGATGCGGAACAGCCGTACACGCCGGTGGCGAGCGTGACGGGAAAGGG
AGAAAGCAGGCAGGTGTGGTATTACCACACGGACGTGACGGGCACGCCGCAGGAGGTGACGGCGGCGGACGGAACGCTGG
TGTGGGCGGGGTATATCAAGGGGTTTGGAGAAAATGCGGCGGACATCAGCAACAGCGGGGCGTACTTTCACCAGCCGCTG
CGGCTGCCGGGGCAGTATTTTGACGACGAGACAGGGCTGCATTACAATCTGTTCAGATATTATGCACCGGAGTGTGGACG
GTTCGTCAGTCAGGATCCGATTGGGCTGGCGGGGGGGCTGAATCTTTACCAGTATGCGCCTAATCCGATTAGATGGATCG
ATCCTTTAGGACTTGCTATCCTGGAGCATCAATCTAATTTTGATGCGGCAAGGAGAACCGGATTTGAAAATGCGGGTATG
ACAAACCCTGAGGATGTCACTTTCTCGAAAGTCGATCCCAAAACTGGTACTGTTGTTGAGTTTAAAGGTCCAAATGGGGC
TAAAGTTGCTTATGATGCACCTCATGCAGATATGGATGTGACAGCAGGGCATGATAAACCACATGTTGGTTGGCAATCCG
CAGGAAAAAGAGGTTCCGGAGGAGCTAATAGAGGTAATATTACTTATGATGGCCCACAACATCCGCATCGCTCTGACTCT
AAGGGAGATGATAAATGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References

(1) Magnus Stårsta et al. (2020) RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium. PLoS Genetics 16(2):e1008607. [PubMed:32053596] experimental


experimental experimental literature