Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) Rhs/-
Location 332552..337836 Replicon chromosome
Accession NC_003197
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Toxin (Protein)


Gene name Rhs Uniprot ID -
Locus tag STM0291 Protein ID NP_459289.1
Coordinates 332552..336646 (+) Length 1365 a.a.

Antitoxin (Protein)


Gene name RhsI Uniprot ID -
Locus tag STM0292 Protein ID NP_459290.1
Coordinates 337096..337836 (+) Length 247 a.a.

Genomic Context

STM0286STM0287STM0288STM0289STM0290STM0291STM0292STM0293STM0294STM0295STM0297STM0298STM0299STM0296
Location: 327731..328519 (789 bp)
Type: Others
Protein ID: NP_459284.1
Location: 328516..328932 (417 bp)
Type: Others
Protein ID: NP_459285.1
Location: 328956..329477 (522 bp)
Type: Others
Protein ID: NP_459286.1
Location: 329874..332063 (2190 bp)
Type: Others
Protein ID: NP_459287.1
Location: 332087..332533 (447 bp)
Type: Others
Protein ID: NP_459288.1
Location: 332552..336646 (4095 bp)
Type: Toxin
Protein ID: NP_459289.1
Location: 337096..337836 (741 bp)
Type: Antitoxin
Protein ID: NP_459290.1
Location: 337830..338276 (447 bp)
Type: Others
Protein ID: NP_459291.1
Location: 338839..339276 (438 bp)
Type: Others
Protein ID: NP_459292.1
Location: 340045..340353 (309 bp)
Type: Others
Protein ID: NP_459293.1
Location: 340756..340953 (198 bp)
Type: Others
Protein ID: NP_446754.1
Location: 341179..341460 (282 bp)
Type: Others
Protein ID: NP_446755.1
Location: 342210..342722 (513 bp)
Type: Others
Protein ID: NP_459297.1
Location: 340455..340703 (249 bp)
Type: Others
Protein ID: NP_446753.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
STM0286327731..328519+789NP_459284.1putative cytoplasmic protein-
STM0287328516..328932+417NP_459285.1putative periplasmic protein-
STM0288328956..329477+522NP_459286.1putative cytoplasmic protein-
STM0289329874..332063+2190NP_459287.1putative cytoplasmic protein-
STM0290332087..332533+447NP_459288.1putative cytoplasmic protein-
STM0291332552..336646+4095NP_459289.1putative RHS-family proteinToxin
STM0292337096..337836+741NP_459290.1putative RHS-family proteinAntitoxin
STM0293337830..338276+447NP_459291.1putative cytoplasmic protein-
STM0294338839..339276+438NP_459292.1putative cytoplasmic protein-
STM0295340045..340353+309NP_459293.1putative cytoplasmic protein-
STM0296340455..340703-249NP_446753.1putative cytoplasmic protein-
STM0297340756..340953+198NP_446754.1putative transposase-
STM0298341179..341460+282NP_446755.1putative integrase core domain protein-
STM0299342210..342722+513NP_459297.1putative outer membrane protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--341179..341460281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF6531

(224-296)

Antitoxin

Bacterial toxin 47

(122-236)


Sequences

Toxin        


Download         Length: 1365 a.a.        Molecular weight: 152023.37 Da        Isoelectric Point: 6.0353

>T10105 NP_459289.1 NC_003197:332552-336646 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MYEAARVDDPIYHTSALAGFLIGAIIGIAIIALAAFAFFSCGFLAGLILGFMADQIASGVLQLGEAIGRSIHHTAGKILT
GSENVSTNSRPAARAVLSTVKCDNHIAEKRIAQGSENIYINSQPAARKDDHTECDAVIEDGSPNVFLGGGTQTVLEISSE
IPDWLRKVVDVLFVVASLLGGLAGAWRQAAKLGTKFGTKCAAKFIGGELVGMAVGEAISGLFSNPVDVTTGQKILLPETD
FTLPGRLPVTCSRFYASHLETVGLLGRGWRLNWETSLRDDDEHITLTGVQGRELRYPKTMLTPGHQIFDPEEQLYLSRLH
DGRYVLHYTDRSYYVFGDFDSDGMAYLLFMETPHRQRIVFGHEGGRLVRIASSSGHHLLLHRTQTPAGERLSRIELVQGG
TRGNLVEYRYDDNGQLTGVVNRAGTQVRQFAYENGLMTAHSNATGFTCRYRWQELDGAPRVTEHDTSDGEHYRFDYDFAA
GTTTVTGRQGETWQWWYDRETYITAHRTPGGGMYRFTYNEDHFPVNIELPGGRTVAYEYDIQNRVVKTTDPEGRVTQTQW
NGEFDEITRTALDDDAVWKTQYNAHGQPVQETDPEGRVTQYAYDEQGQMCSRTDAAGGTVVTAFDSRGQMTRYTDCSGRS
TGYDHDEDGNLTRVTDAEGKVVRISYNRLGLPETVNSPGKQQDRYTWNALGLMSSHRRITGSVESWRYTPRGLLAAHTDE
EKRETRWQYTPEGRVAALTNGNGAQYRFSHDADGRLVREVRPDGLSRTFILDDSGYLTAIQTTGTQGGVRRETQQRDALG
RLLRTENEHGQRTFSYNRLDQITAVTLTPTEAGQQQHRMQADTVRFEYDRSGWLTAEHAGNGSICYQRDALGNPTDITLP
DGQHLTHLYYGSGHLLQTALDGLTVSEYERDSLHRQIMRTQGQLATYSGYDDDGLLSWQRSLASGSAPVLPGQRPARQGC
VTSRDYYWNNHGEVGTIDDGLRGSVVYSYDRSGYLTGRSGQMYDHDRYYYDKAGNLLDNEGQGAVMSNRLPGCGRDRYGY
NEWGELTTRRDQQLEWNAQGQLTRVISGNTETHYGYDALGRRTRKATYGRHTGHTARSRTDFVWEGFRLLQENVQQQGWR
TYLYDAEQPYTPVASVTGRGESRQVWYYHTDVTGTPQEVTAADGTLVWAGYIRGFGENAADISNSGAYFHQPLRLPGQYF
DDETGLHYNLFRYYAPECGRFVSQDPIGLRGGLNLYQYAPNPLKYIDPLGLTATVGRWMGPAEYQQMLDTGTVVQSSTGT
THVAYPADIDAFGKQAKNGAMYVEFDVPEKSLVPTNEGWAKIVGPDSIEGRLAKRKGLPVPEMPTAENITVRGEKINGEV
EAKC

Download         Length: 4095 bp

>T10105 NC_003197:332552-336646 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGTATGAAGCAGCCCGTGTGGATGATCCTATCTACCACACCAGCGCGCTCGCCGGGTTTCTTATCGGCGCTATCATCGG
CATCGCCATTATCGCGCTTGCCGCCTTTGCCTTCTTTAGCTGCGGTTTTCTTGCCGGGCTGATTCTGGGTTTTATGGCCG
ATCAAATAGCCTCCGGGGTATTGCAACTGGGCGAGGCCATCGGGCGCTCCATCCACCACACGGCAGGAAAAATCCTCACC
GGTTCGGAGAATGTCAGCACCAACAGTCGCCCGGCGGCGCGCGCGGTACTGAGTACGGTGAAATGCGATAACCATATCGC
AGAAAAACGCATCGCCCAAGGGTCGGAAAATATCTACATCAACAGCCAGCCCGCCGCCCGTAAGGATGACCACACCGAAT
GCGACGCGGTGATTGAAGACGGTTCGCCGAATGTGTTTCTCGGCGGCGGCACACAGACGGTACTGGAAATCAGTTCTGAA
ATTCCGGACTGGCTGCGCAAGGTGGTGGATGTATTGTTTGTCGTGGCGAGTCTGCTCGGCGGGCTGGCCGGGGCGTGGCG
GCAGGCGGCAAAGCTGGGGACGAAATTTGGCACTAAATGTGCCGCTAAGTTTATCGGCGGGGAGCTTGTCGGGATGGCCG
TGGGTGAGGCTATCAGCGGGCTGTTCAGCAATCCGGTGGATGTGACCACCGGGCAGAAAATCCTGCTGCCGGAAACGGAC
TTCACCCTGCCCGGTCGCCTGCCGGTCACCTGCTCGCGTTTTTACGCCAGCCACCTGGAAACTGTGGGACTGTTGGGACG
GGGCTGGCGGCTGAACTGGGAAACCAGCCTGCGCGATGACGATGAACACATCACGCTGACCGGCGTACAGGGGCGGGAAC
TGCGTTACCCGAAAACGATGCTGACGCCCGGCCACCAGATATTTGACCCGGAAGAACAGTTATACCTCAGCCGCCTGCAT
GACGGGCGTTACGTGCTGCATTACACCGATCGCAGCTATTACGTATTTGGTGATTTTGACAGTGACGGCATGGCATACCT
GCTGTTTATGGAGACGCCGCACCGCCAGCGCATTGTCTTCGGGCACGAAGGAGGCAGACTGGTACGGATAGCCTCCAGCA
GCGGGCATCACCTGTTACTGCACCGCACACAGACCCCGGCAGGGGAGCGGCTGTCGCGAATTGAACTGGTGCAGGGCGGC
ACCCGTGGCAATCTGGTGGAGTACCGGTATGACGATAACGGTCAACTGACCGGCGTGGTGAACCGGGCGGGAACGCAGGT
GCGTCAGTTTGCTTATGAAAACGGGCTGATGACGGCGCACAGCAATGCGACGGGGTTCACCTGCCGCTACCGCTGGCAGG
AACTCGACGGCGCGCCGCGCGTGACGGAGCACGACACCAGTGACGGCGAACATTACCGCTTTGACTATGATTTTGCCGCA
GGCACCACCACCGTCACCGGCAGGCAGGGGGAGACATGGCAGTGGTGGTACGACAGGGAAACGTATATCACCGCGCACCG
GACGCCGGGCGGTGGAATGTACCGCTTCACGTACAACGAAGACCACTTCCCTGTCAACATTGAGCTGCCCGGCGGTCGCA
CGGTGGCGTATGAATATGACATCCAGAACCGGGTGGTGAAGACGACAGATCCGGAAGGCCGGGTGACGCAGACGCAGTGG
AACGGCGAGTTCGACGAAATCACGCGCACGGCGCTGGACGATGACGCTGTCTGGAAAACGCAGTACAACGCCCACGGCCA
GCCAGTGCAGGAGACGGACCCGGAAGGGCGGGTGACGCAGTACGCTTACGATGAACAGGGGCAGATGTGCAGCCGGACGG
ATGCGGCGGGCGGCACGGTGGTGACGGCGTTCGACAGCCGGGGGCAGATGACGCGGTACACCGACTGTTCAGGGCGCAGC
ACAGGATATGACCACGATGAGGACGGCAACCTGACGCGGGTGACGGACGCGGAAGGGAAGGTGGTACGCATCAGCTACAA
CCGACTTGGGTTGCCGGAGACGGTAAACTCACCGGGGAAACAGCAGGACAGGTATACCTGGAATGCGCTGGGGCTGATGA
GCAGCCACCGGCGCATCACGGGGAGCGTGGAGAGCTGGCGGTATACGCCGCGCGGTCTGCTGGCGGCGCACACGGATGAG
GAGAAGCGCGAGACGCGCTGGCAGTACACGCCGGAAGGCCGGGTGGCAGCGCTGACCAACGGCAACGGGGCGCAGTACCG
GTTCAGTCACGATGCGGACGGCAGGCTGGTGCGTGAGGTTCGCCCGGACGGACTGAGCCGTACTTTTATCCTGGACGACA
GCGGTTATCTGACGGCGATACAGACCACGGGCACGCAGGGCGGCGTGCGGCGGGAGACGCAGCAGCGGGATGCGCTGGGC
CGTCTGTTACGGACGGAGAATGAACACGGCCAGCGGACGTTCAGCTACAACCGGCTGGACCAGATAACGGCAGTGACGCT
CACGCCCACGGAGGCGGGGCAACAGCAGCACCGGATGCAGGCCGACACGGTGCGTTTTGAGTATGACCGCAGCGGCTGGC
TGACGGCGGAGCACGCGGGGAACGGTAGCATATGTTATCAGCGCGACGCGCTGGGCAACCCGACGGACATCACGCTGCCG
GACGGGCAGCACCTGACGCATCTGTATTACGGGAGCGGGCATCTGTTACAGACGGCGCTGGACGGCCTGACGGTGAGCGA
GTATGAGCGCGACAGCCTGCACCGTCAGATAATGCGCACGCAGGGGCAGCTTGCGACGTACAGCGGCTATGACGACGACG
GGCTGCTGAGCTGGCAGCGCAGTCTGGCGTCCGGCAGTGCCCCTGTTCTTCCTGGCCAGCGCCCGGCGCGGCAGGGCTGC
GTGACGTCGAGGGACTATTACTGGAACAACCACGGCGAGGTGGGCACGATTGACGACGGCCTGCGTGGCAGCGTGGTGTA
CAGCTATGACAGAAGCGGTTACCTGACCGGGCGCTCAGGTCAGATGTATGACCATGACCGTTATTATTACGATAAGGCGG
GCAACCTGCTGGATAACGAAGGGCAGGGAGCGGTGATGAGCAACCGGCTGCCGGGCTGTGGTCGTGACCGTTACGGCTAT
AACGAGTGGGGCGAGCTGACCACGCGGCGCGACCAGCAACTGGAGTGGAACGCGCAGGGGCAGCTGACGCGGGTCATCAG
CGGCAACACGGAGACGCACTACGGCTACGATGCGCTGGGGAGGCGAACCCGCAAGGCGACGTACGGGCGGCACACGGGCC
ATACGGCGCGGAGCCGGACGGACTTTGTGTGGGAGGGGTTCAGGCTGTTGCAGGAGAACGTGCAGCAGCAGGGCTGGCGG
ACCTATCTGTACGATGCGGAACAGCCGTACACGCCGGTGGCGAGCGTGACGGGGCGGGGAGAAAGCAGGCAGGTGTGGTA
TTACCACACGGATGTGACGGGCACGCCGCAGGAGGTGACGGCGGCGGACGGAACGCTGGTGTGGGCGGGGTATATCAGGG
GGTTTGGAGAGAATGCGGCGGACATCAGCAACAGCGGGGCGTACTTTCACCAGCCGCTGCGGCTGCCGGGGCAGTATTTT
GACGACGAGACAGGGCTGCATTACAATCTGTTCAGATATTATGCACCGGAGTGTGGACGGTTTGTCAGTCAGGATCCGAT
CGGGCTGAGGGGCGGGTTAAACCTTTATCAGTATGCGCCAAATCCTCTCAAATATATAGACCCACTTGGTTTAACCGCGA
CTGTTGGGCGATGGATGGGGCCTGCGGAATATCAGCAAATGCTTGATACTGGGACAGTAGTACAAAGTTCAACAGGGACA
ACTCATGTTGCCTACCCTGCTGATATAGATGCTTTTGGTAAGCAAGCAAAAAATGGTGCTATGTATGTTGAATTTGATGT
GCCTGAAAAATCATTAGTACCTACAAATGAAGGATGGGCAAAAATAGTAGGGCCAGATTCTATCGAAGGGCGATTAGCTA
AACGCAAAGGTTTGCCTGTTCCTGAAATGCCAACAGCAGAAAACATAACTGTAAGGGGCGAGAAAATTAATGGGGAAGTT
GAAGCAAAATGCTAA

Antitoxin


Download         Length: 247 a.a.        Molecular weight: 26961.56 Da        Isoelectric Point: 5.7786

>AT10105 NP_459290.1 NC_003197:337096-337836 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
VQQQGWRTYLYDAEQPYTPVASVTGKGESRQVWYYHTDVTGTPQEVTAADGTLVWAGYIKGFGENAADISNSGAYFHQPL
RLPGQYFDDETGLHYNLFRYYAPECGRFVSQDPIGLAGGLNLYQYAPNPIRWIDPLGLAILEHQSNFDAARRTGFENAGM
TNPEDVTFSKVDPKTGTVVEFKGPNGAKVAYDAPHADMDVTAGHDKPHVGWQSAGKRGSGGANRGNITYDGPQHPHRSDS
KGDDKC

Download         Length: 741 bp

>AT10105 NC_003197:337096-337836 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
GTGCAGCAGCAGGGCTGGCGGACATATCTGTACGATGCGGAACAGCCGTACACGCCGGTGGCGAGCGTGACGGGAAAGGG
AGAAAGCAGGCAGGTGTGGTATTACCACACGGACGTGACGGGCACGCCGCAGGAGGTGACGGCGGCGGACGGAACGCTGG
TGTGGGCGGGGTATATCAAGGGGTTTGGAGAAAATGCGGCGGACATCAGCAACAGCGGGGCGTACTTTCACCAGCCGCTG
CGGCTGCCGGGGCAGTATTTTGACGACGAGACAGGGCTGCATTACAATCTGTTCAGATATTATGCACCGGAGTGTGGACG
GTTCGTCAGTCAGGATCCGATTGGGCTGGCGGGGGGGCTGAATCTTTACCAGTATGCGCCTAATCCGATTAGATGGATCG
ATCCTTTAGGACTTGCTATCCTGGAGCATCAATCTAATTTTGATGCGGCAAGGAGAACCGGATTTGAAAATGCGGGTATG
ACAAACCCTGAGGATGTCACTTTCTCGAAAGTCGATCCCAAAACTGGTACTGTTGTTGAGTTTAAAGGTCCAAATGGGGC
TAAAGTTGCTTATGATGCACCTCATGCAGATATGGATGTGACAGCAGGGCATGATAAACCACATGTTGGTTGGCAATCCG
CAGGAAAAAGAGGTTCCGGAGGAGCTAATAGAGGTAATATTACTTATGATGGCCCACAACATCCGCATCGCTCTGACTCT
AAGGGAGATGATAAATGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) Magnus Stårsta et al. (2020) RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium. PLoS Genetics 16(2):e1008607. [PubMed:32053596] experimental


experimental experimental literature