282664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3694058..3694490 Replicon chromosome
Accession NZ_CP126138
Organism Salmonella enterica subsp. enterica serovar Kottbus strain DSK01

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag QNM33_RS18280 Protein ID WP_000994224.1
Coordinates 3694215..3694490 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3694058..3694480 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM33_RS18250 3690276..3691013 - 738 WP_001535430.1 pili assembly chaperone SafB -
QNM33_RS18255 3691097..3691609 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
QNM33_RS18260 3692359..3693063 - 705 Protein_3569 integrase core domain-containing protein -
QNM33_RS18265 3693116..3693364 + 249 WP_001738030.1 SymE family type I addiction module toxin -
QNM33_RS18270 3693466..3693774 - 309 WP_080247984.1 hypothetical protein -
QNM33_RS18275 3693857..3693973 - 117 WP_227457392.1 hypothetical protein -
- 3694058..3694480 - 423 - - Antitoxin
QNM33_RS18280 3694215..3694490 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
QNM33_RS18285 3694543..3694980 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
QNM33_RS18290 3695543..3695989 - 447 WP_000935097.1 protein SciX -
QNM33_RS18295 3695983..3696852 - 870 Protein_3576 polymorphic toxin type 47 domain-containing protein -
QNM33_RS18300 3696916..3697179 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3683206..3697179 13973
flank IS/Tn - - 3692359..3692640 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T282664 WP_000994224.1 NZ_CP126138:3694215-3694490 [Salmonella enterica subsp. enterica serovar Kottbus]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT282664 NZ_CP126138:c3694480-3694058 [Salmonella enterica subsp. enterica serovar Kottbus]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References