270727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3731107..3731521 Replicon chromosome
Accession NZ_CP117351
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM100

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag PQQ10_RS18595 Protein ID WP_000994230.1
Coordinates 3731264..3731521 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3731107..3731439 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ10_RS18555 3726368..3726820 - 453 WP_001675682.1 Saf-pilin pilus formation protein SafA -
PQQ10_RS18560 3727629..3728199 - 571 Protein_3635 integrase core domain-containing protein -
PQQ10_RS18565 3728120..3728329 - 210 WP_001676010.1 hypothetical protein -
PQQ10_RS18570 3728382..3728696 + 315 WP_072100769.1 SymE family type I addiction module toxin -
PQQ10_RS18575 3728763..3729041 - 279 WP_012543321.1 hypothetical protein -
PQQ10_RS18580 3729357..3729824 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
PQQ10_RS18585 3729821..3730138 - 318 WP_001751277.1 hypothetical protein -
PQQ10_RS18590 3730696..3730929 - 234 WP_124084119.1 hypothetical protein -
- 3731107..3731439 - 333 - - Antitoxin
PQQ10_RS18595 3731264..3731521 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
PQQ10_RS18600 3731587..3732033 - 447 WP_000171102.1 hypothetical protein -
PQQ10_RS18605 3732030..3734852 - 2823 Protein_3644 RHS repeat-associated core domain-containing protein -
PQQ10_RS18610 3734843..3735109 + 267 WP_223151220.1 SymE family type I addiction module toxin -
PQQ10_RS18615 3735227..3735565 - 339 WP_000201550.1 hypothetical protein -
PQQ10_RS18620 3735587..3735907 - 321 WP_016695071.1 HNH endonuclease -
PQQ10_RS18625 3735965..3736248 - 284 Protein_3648 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3720800..3736801 16001
flank IS/Tn - - 3727629..3727907 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T270727 WP_000994230.1 NZ_CP117351:3731264-3731521 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT270727 NZ_CP117351:c3731439-3731107 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References