221457

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 4695712..4696126 Replicon chromosome
Accession NZ_CP085797
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF56_RS22865 Protein ID WP_000994230.1
Coordinates 4695869..4696126 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 4695712..4696044 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF56_RS22825 4690973..4691470 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LJF56_RS22830 4692233..4692803 - 571 Protein_4445 integrase core domain-containing protein -
LJF56_RS22835 4692724..4692933 - 210 WP_001676010.1 hypothetical protein -
LJF56_RS22840 4692986..4693300 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF56_RS22845 4693367..4693645 - 279 WP_012543321.1 hypothetical protein -
LJF56_RS22850 4693962..4694429 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF56_RS22855 4694426..4694743 - 318 WP_001751277.1 hypothetical protein -
LJF56_RS22860 4695301..4695534 - 234 WP_124084119.1 hypothetical protein -
- 4695712..4696044 - 333 - - Antitoxin
LJF56_RS22865 4695869..4696126 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LJF56_RS22870 4696192..4696638 - 447 WP_000171102.1 hypothetical protein -
LJF56_RS22875 4696635..4700009 - 3375 Protein_4454 RHS domain-containing protein -
LJF56_RS22880 4700009..4700515 - 507 Protein_4455 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4683077..4699931 16854
flank IS/Tn - - 4692233..4692511 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221457 WP_000994230.1 NZ_CP085797:4695869-4696126 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221457 NZ_CP117396:839553-839966 [Salmonella enterica subsp. enterica serovar Uganda]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 333 bp

>AT221457 NZ_CP085797:c4696044-4695712 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References