222562

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3709894..3710326 Replicon chromosome
Accession NZ_CP086118
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S34

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag LLY43_RS18270 Protein ID WP_000994224.1
Coordinates 3710051..3710326 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3709894..3710316 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLY43_RS18240 3706112..3706849 - 738 WP_001535430.1 pili assembly chaperone SafB -
LLY43_RS18245 3706933..3707445 - 513 WP_077248260.1 pilus assembly protein -
LLY43_RS18250 3708195..3708899 - 705 Protein_3573 integrase core domain-containing protein -
LLY43_RS18255 3708952..3709200 + 249 WP_001738030.1 SymE family type I addiction module toxin -
LLY43_RS18260 3709302..3709610 - 309 WP_010988969.1 hypothetical protein -
LLY43_RS18265 3709693..3709809 - 117 WP_227457392.1 hypothetical protein -
- 3709894..3710316 - 423 - - Antitoxin
LLY43_RS18270 3710051..3710326 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
LLY43_RS18275 3710379..3710816 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
LLY43_RS18280 3711379..3711825 - 447 WP_000935097.1 protein SciX -
LLY43_RS18285 3711819..3712688 - 870 Protein_3580 polymorphic toxin type 47 domain-containing protein -
LLY43_RS18290 3712752..3713015 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3699042..3713015 13973
flank IS/Tn - - 3708195..3708476 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T222562 WP_000994224.1 NZ_CP086118:3710051-3710326 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T222562 NZ_CP117962:1264820-1265098 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 423 bp

>AT222562 NZ_CP086118:c3710316-3709894 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References