230372

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 339329..339761 Replicon chromosome
Accession NZ_CP090304
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ZJUJY

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag LPC12_RS01495 Protein ID WP_000994224.1
Coordinates 339329..339604 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 339339..339761 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC12_RS01475 336640..336903 + 264 WP_000932531.1 hypothetical protein -
LPC12_RS01480 336967..337836 + 870 Protein_288 polymorphic toxin type 47 domain-containing protein -
LPC12_RS01485 337830..338276 + 447 WP_000935097.1 protein SciX -
LPC12_RS01490 338839..339276 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
LPC12_RS01495 339329..339604 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 339339..339761 + 423 - - Antitoxin
LPC12_RS01500 339789..339962 + 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
LPC12_RS01505 340045..340353 + 309 WP_010988969.1 hypothetical protein -
LPC12_RS01510 340455..340703 - 249 WP_001738030.1 SymE family type I addiction module toxin -
LPC12_RS01515 340756..341460 + 705 Protein_295 integrase core domain-containing protein -
LPC12_RS01520 342210..342722 + 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
LPC12_RS01525 342806..343543 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 337063..351351 14288
flank IS/Tn - - 341179..341460 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T230372 WP_000994224.1 NZ_CP090304:c339604-339329 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T230372 NZ_CP124886:606640-606756 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 423 bp

>AT230372 NZ_CP090304:339339-339761 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References