257746

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3602297..3602711 Replicon chromosome
Accession NZ_CP104358
Organism Salmonella enterica strain PNUSAS119065

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag N4275_RS17730 Protein ID WP_000994230.1
Coordinates 3602454..3602711 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3602297..3602629 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4275_RS17690 3597558..3598055 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
N4275_RS17695 3598818..3599388 - 571 Protein_3460 integrase core domain-containing protein -
N4275_RS17700 3599309..3599518 - 210 WP_001676010.1 hypothetical protein -
N4275_RS17705 3599571..3599885 + 315 WP_072100769.1 SymE family type I addiction module toxin -
N4275_RS17710 3599952..3600230 - 279 WP_012543321.1 hypothetical protein -
N4275_RS17715 3600547..3601014 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
N4275_RS17720 3601011..3601328 - 318 WP_001751277.1 hypothetical protein -
N4275_RS17725 3601886..3602119 - 234 WP_124084119.1 hypothetical protein -
- 3602297..3602629 - 333 - - Antitoxin
N4275_RS17730 3602454..3602711 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
N4275_RS17735 3602777..3603223 - 447 WP_000171102.1 hypothetical protein -
N4275_RS17740 3603220..3606594 - 3375 Protein_3469 RHS domain-containing protein -
N4275_RS17745 3606594..3607100 - 507 Protein_3470 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3591989..3606516 14527
flank IS/Tn - - 3598818..3599096 278
- inside Genomic island - - 3589662..3606516 16854


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T257746 WP_000994230.1 NZ_CP104358:3602454-3602711 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT257746 NZ_CP104358:c3602629-3602297 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References