251959

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 4052719..4053151 Replicon chromosome
Accession NZ_CP101372
Organism Salmonella enterica strain SC2016025

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NMU31_RS20195 Protein ID WP_000994224.1
Coordinates 4052876..4053151 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 4052719..4053141 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU31_RS20165 4048937..4049674 - 738 WP_001535430.1 pili assembly chaperone SafB -
NMU31_RS20170 4049758..4050270 - 513 WP_077248260.1 pilus assembly protein -
NMU31_RS20175 4051020..4051724 - 705 Protein_3954 integrase core domain-containing protein -
NMU31_RS20180 4051777..4052025 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NMU31_RS20185 4052127..4052435 - 309 WP_010988969.1 hypothetical protein -
NMU31_RS20190 4052518..4052634 - 117 WP_227457392.1 hypothetical protein -
- 4052719..4053141 - 423 - - Antitoxin
NMU31_RS20195 4052876..4053151 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NMU31_RS20200 4053204..4053641 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NMU31_RS20205 4054204..4054650 - 447 WP_000935097.1 protein SciX -
NMU31_RS20210 4054644..4055513 - 870 Protein_3961 polymorphic toxin type 47 domain-containing protein -
NMU31_RS20215 4055577..4055840 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4041867..4055840 13973
flank IS/Tn - - 4051020..4051301 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T251959 WP_000994224.1 NZ_CP101372:4052876-4053151 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT251959 NZ_CP101372:c4053141-4052719 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References