270912

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3741054..3741468 Replicon chromosome
Accession NZ_CP117373
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM043

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag PQQ08_RS18650 Protein ID WP_000994230.1
Coordinates 3741211..3741468 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3741054..3741386 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ08_RS18610 3736320..3736813 - 494 Protein_3644 pilus assembly protein -
PQQ08_RS18615 3737578..3738148 - 571 Protein_3645 integrase core domain-containing protein -
PQQ08_RS18620 3738069..3738278 - 210 WP_001676010.1 hypothetical protein -
PQQ08_RS18625 3738331..3738645 + 315 WP_072100769.1 SymE family type I addiction module toxin -
PQQ08_RS18630 3738712..3738990 - 279 WP_012543321.1 hypothetical protein -
PQQ08_RS18635 3739306..3739773 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
PQQ08_RS18640 3739770..3740138 - 369 WP_274896614.1 hypothetical protein -
PQQ08_RS18645 3740643..3740876 - 234 WP_124084119.1 hypothetical protein -
- 3741054..3741386 - 333 - - Antitoxin
PQQ08_RS18650 3741211..3741468 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
PQQ08_RS18655 3741534..3741980 - 447 WP_000171102.1 hypothetical protein -
PQQ08_RS18660 3741977..3744799 - 2823 Protein_3654 RHS repeat-associated core domain-containing protein -
PQQ08_RS18665 3744790..3745056 + 267 WP_223151220.1 SymE family type I addiction module toxin -
PQQ08_RS18670 3745174..3745512 - 339 WP_000201550.1 hypothetical protein -
PQQ08_RS18675 3745534..3745854 - 321 WP_016695071.1 HNH endonuclease -
PQQ08_RS18680 3745912..3746195 - 284 Protein_3658 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3728425..3746748 18323
flank IS/Tn - - 3737578..3737856 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T270912 WP_000994230.1 NZ_CP117373:3741211-3741468 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT270912 NZ_CP117373:c3741386-3741054 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References