253919

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3809184..3809616 Replicon chromosome
Accession NZ_CP102669
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NUW86_RS18995 Protein ID WP_000994224.1
Coordinates 3809341..3809616 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3809184..3809606 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUW86_RS18965 3805402..3806139 - 738 WP_001535430.1 pili assembly chaperone SafB -
NUW86_RS18970 3806223..3806735 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
NUW86_RS18975 3807485..3808189 - 705 Protein_3713 integrase core domain-containing protein -
NUW86_RS18980 3808242..3808490 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NUW86_RS18985 3808592..3808900 - 309 WP_010988969.1 hypothetical protein -
NUW86_RS18990 3808983..3809099 - 117 WP_227457392.1 hypothetical protein -
- 3809184..3809606 - 423 - - Antitoxin
NUW86_RS18995 3809341..3809616 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NUW86_RS19000 3809669..3810106 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NUW86_RS19005 3810669..3811115 - 447 WP_000935097.1 protein SciX -
NUW86_RS19010 3811109..3811978 - 870 Protein_3720 polymorphic toxin type 47 domain-containing protein -
NUW86_RS19015 3812042..3812305 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3798332..3812305 13973
flank IS/Tn - - 3807485..3807766 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T253919 WP_000994224.1 NZ_CP102669:3809341-3809616 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT253919 NZ_CP102669:c3809606-3809184 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References