186436

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 994662..995094 Replicon chromosome
Accession NZ_CP068018
Organism Salmonella enterica strain 1722

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag JI996_RS04700 Protein ID WP_000994224.1
Coordinates 994662..994937 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 994672..995094 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI996_RS04680 991973..992236 + 264 WP_000932531.1 hypothetical protein -
JI996_RS04685 992300..993169 + 870 Protein_908 polymorphic toxin type 47 domain-containing protein -
JI996_RS04690 993163..993609 + 447 WP_000935097.1 protein SciX -
JI996_RS04695 994172..994609 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
JI996_RS04700 994662..994937 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 994672..995094 + 423 - - Antitoxin
JI996_RS04705 995179..995295 + 117 WP_227457392.1 hypothetical protein -
JI996_RS04710 995378..995686 + 309 WP_010988969.1 hypothetical protein -
JI996_RS04715 995788..996036 - 249 WP_001738030.1 SymE family type I addiction module toxin -
JI996_RS04720 996089..996793 + 705 Protein_915 integrase core domain-containing protein -
JI996_RS04725 997543..998055 + 513 WP_077248260.1 pilus assembly protein -
JI996_RS04730 998139..998876 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 991973..1004891 12918
flank IS/Tn - - 996512..996793 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T186436 WP_000994224.1 NZ_CP068018:c994937-994662 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T186436 NZ_CP089441:706807-707295 [Klebsiella quasipneumoniae]
ATGATCTCCGCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTAAAACTGCGGGCGATGAAAAATCAGACCACTGGCGCGTCTCGTACCTTTGTGTGTTGTGGCAGCGATTCTAACGTGC
TGGCTTTTTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCTCCCGGTCGCTTTCGCCGCAATATGCCTGACCCG
ATCCCTGTGGTGGTGCTGGGCCGTCTGGCGGTGGATCGGTCGCTACATGGACAAGGTGTTGGGCGGGCGCTGGTGAGGGA
TGCCGGACTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGTGGGATGTTGGTCCATGCCTTGTCGGATGAAGCGC
GGGAGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACATTGGGGGATTTGGTT
CATGCCTGA

Antitoxin


Download         Length: 423 bp

>AT186436 NZ_CP068018:994672-995094 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References