265928

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3704130..3704562 Replicon chromosome
Accession NZ_CP113536
Organism Salmonella enterica strain ZCX

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag OXV07_RS18255 Protein ID WP_000994224.1
Coordinates 3704287..3704562 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3704130..3704552 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV07_RS18225 3700348..3701085 - 738 WP_001535430.1 pili assembly chaperone SafB -
OXV07_RS18230 3701169..3701681 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
OXV07_RS18235 3702431..3703135 - 705 Protein_3567 integrase core domain-containing protein -
OXV07_RS18240 3703188..3703436 + 249 WP_001738030.1 SymE family type I addiction module toxin -
OXV07_RS18245 3703538..3703846 - 309 WP_010988969.1 hypothetical protein -
OXV07_RS18250 3703929..3704045 - 117 WP_227457392.1 hypothetical protein -
- 3704130..3704552 - 423 - - Antitoxin
OXV07_RS18255 3704287..3704562 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
OXV07_RS18260 3704615..3705052 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
OXV07_RS18265 3705615..3706061 - 447 WP_000935097.1 protein SciX -
OXV07_RS18270 3706055..3706924 - 870 Protein_3574 polymorphic toxin type 47 domain-containing protein -
OXV07_RS18275 3706988..3707251 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3693278..3707251 13973
flank IS/Tn - - 3702431..3702712 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T265928 WP_000994224.1 NZ_CP113536:3704287-3704562 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT265928 NZ_CP113536:c3704552-3704130 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References