270879

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3725691..3726123 Replicon chromosome
Accession NZ_CP117370
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain RM054

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag PQP97_RS18480 Protein ID WP_000994224.1
Coordinates 3725848..3726123 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3725691..3726113 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP97_RS18450 3721909..3722646 - 738 WP_001535430.1 pili assembly chaperone SafB -
PQP97_RS18455 3722730..3723242 - 513 WP_077248260.1 pilus assembly protein -
PQP97_RS18460 3723992..3724696 - 705 Protein_3611 integrase core domain-containing protein -
PQP97_RS18465 3724749..3724997 + 249 WP_001738030.1 SymE family type I addiction module toxin -
PQP97_RS18470 3725099..3725407 - 309 WP_010988969.1 hypothetical protein -
PQP97_RS18475 3725490..3725606 - 117 WP_227457392.1 hypothetical protein -
- 3725691..3726113 - 423 - - Antitoxin
PQP97_RS18480 3725848..3726123 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
PQP97_RS18485 3726176..3726613 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
PQP97_RS18490 3727176..3727622 - 447 WP_000935097.1 protein SciX -
PQP97_RS18495 3727616..3728485 - 870 Protein_3618 polymorphic toxin type 47 domain-containing protein -
PQP97_RS18500 3728549..3728812 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3714839..3728812 13973
flank IS/Tn - - 3723992..3724273 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T270879 WP_000994224.1 NZ_CP117370:3725848-3726123 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT270879 NZ_CP117370:c3726113-3725691 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References