270533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3569508..3569940 Replicon chromosome
Accession NZ_CP117327
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain RM106

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag PQP95_RS17370 Protein ID WP_000994224.1
Coordinates 3569665..3569940 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3569508..3569930 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP95_RS17340 3565726..3566463 - 738 WP_001535430.1 pili assembly chaperone SafB -
PQP95_RS17345 3566547..3567059 - 513 WP_274891138.1 pilus assembly protein -
PQP95_RS17350 3567809..3568513 - 705 Protein_3388 integrase core domain-containing protein -
PQP95_RS17355 3568566..3568814 + 249 WP_001738030.1 SymE family type I addiction module toxin -
PQP95_RS17360 3568916..3569224 - 309 WP_010988969.1 hypothetical protein -
PQP95_RS17365 3569307..3569423 - 117 WP_227457392.1 hypothetical protein -
- 3569508..3569930 - 423 - - Antitoxin
PQP95_RS17370 3569665..3569940 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
PQP95_RS17375 3569993..3570430 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
PQP95_RS17380 3570994..3571440 - 447 WP_023137639.1 protein SciX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3558650..3571440 12790
flank IS/Tn - - 3567809..3568090 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T270533 WP_000994224.1 NZ_CP117327:3569665-3569940 [Salmonella enterica subsp. enterica serovar Saintpaul]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT270533 NZ_CP117327:c3569930-3569508 [Salmonella enterica subsp. enterica serovar Saintpaul]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References