Detailed information of TA system TA170627

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1271946..1272360
• Replicon: chromosome
• Accession: NZ_CP060672
• Organism: Salmonella enterica strain 190729_8

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: M7RBD3
• Locus tag: H9Q85_RS05910
• Protein ID: WP_000994230.1
• Coordinates: 1271946..1272203 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1272028..1272360 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q85_RS05895	1267557..1268063	+	507	Protein_1134	phage late control D family protein	-
H9Q85_RS05900	1268063..1271437	+	3375	Protein_1135	RHS domain-containing protein	-
H9Q85_RS05905	1271434..1271880	+	447	WP_000171102.1	hypothetical protein	-
H9Q85_RS05910	1271946..1272203	-	258	WP_000994230.1	SymE family type I addiction module toxin	Toxin
-	1272028..1272360	+	333	-	-	Antitoxin
H9Q85_RS05915	1272538..1272771	+	234	WP_124084119.1	hypothetical protein	-
H9Q85_RS05920	1273329..1273646	+	318	WP_001751277.1	hypothetical protein	-
H9Q85_RS05925	1273643..1274110	+	468	WP_000828182.1	sugar tyrosine-protein kinase	-
H9Q85_RS05930	1274427..1274705	+	279	WP_012543321.1	hypothetical protein	-
H9Q85_RS05935	1274772..1275086	-	315	WP_072100769.1	SymE family type I addiction module toxin	-
H9Q85_RS05940	1275139..1275348	+	210	WP_001676010.1	hypothetical protein	-
H9Q85_RS05945	1275269..1275839	+	571	Protein_1144	integrase core domain-containing protein	-
H9Q85_RS05950	1276602..1277099	+	498	WP_016695185.1	Saf-pilin pilus formation protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1266642..1285733	19091
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003197 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 IS/Tn TA010105 341179..341460 0.009 View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA010103 340656..340937 0.009 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026042 341863..342144 0.009	flank	IS/Tn	-	-	1275561..1275839	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.94 Da
• Isoelectric Point: 9.5519

>T170627 WP_000994230.1 NZ_CP060672:c1272203-1271946 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Nucleotide

• Length: 258 bp

>T170627 NZ_CP077661:c2545691-2545473 [Enterobacter cloacae complex sp. ECL112]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAAAAAAATAAATACGAGCTCTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TAACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT170627 NZ_CP060672:1272028-1272360 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A656IER2

Antitoxin