231029

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3744418..3744850 Replicon chromosome
Accession NZ_CP090529
Organism Salmonella enterica strain 2008079-SE

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag L0F60_RS18525 Protein ID WP_000994224.1
Coordinates 3744575..3744850 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3744418..3744840 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F60_RS18495 3740636..3741373 - 738 WP_001535430.1 pili assembly chaperone SafB -
L0F60_RS18500 3741457..3741969 - 513 WP_077248260.1 pilus assembly protein -
L0F60_RS18505 3742719..3743423 - 705 Protein_3629 integrase core domain-containing protein -
L0F60_RS18510 3743476..3743724 + 249 WP_001738030.1 SymE family type I addiction module toxin -
L0F60_RS18515 3743826..3744134 - 309 WP_010988969.1 hypothetical protein -
L0F60_RS18520 3744217..3744333 - 117 WP_227457392.1 hypothetical protein -
- 3744418..3744840 - 423 - - Antitoxin
L0F60_RS18525 3744575..3744850 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
L0F60_RS18530 3744903..3745340 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
L0F60_RS18535 3745903..3746349 - 447 WP_000935097.1 protein SciX -
L0F60_RS18540 3746343..3747212 - 870 Protein_3636 polymorphic toxin type 47 domain-containing protein -
L0F60_RS18545 3747276..3747539 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3733566..3747539 13973
flank IS/Tn - - 3742719..3743000 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T231029 WP_000994224.1 NZ_CP090529:3744575-3744850 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T231029 NZ_CP125897:358370-358546 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 423 bp

>AT231029 NZ_CP090529:c3744840-3744418 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References