221417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1548022..1548436 Replicon chromosome
Accession NZ_CP085796
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Froakie

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF57_RS07235 Protein ID WP_000994230.1
Coordinates 1548022..1548279 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1548104..1548436 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF57_RS07220 1543633..1544139 + 507 Protein_1392 phage late control D family protein -
LJF57_RS07225 1544139..1547513 + 3375 Protein_1393 RHS domain-containing protein -
LJF57_RS07230 1547510..1547956 + 447 WP_000171102.1 hypothetical protein -
LJF57_RS07235 1548022..1548279 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 1548104..1548436 + 333 - - Antitoxin
LJF57_RS07240 1548614..1548847 + 234 WP_124084119.1 hypothetical protein -
LJF57_RS07245 1549405..1549722 + 318 WP_001751277.1 hypothetical protein -
LJF57_RS07250 1549719..1550186 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF57_RS07255 1550503..1550781 + 279 WP_012543321.1 hypothetical protein -
LJF57_RS07260 1550848..1551162 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF57_RS07265 1551215..1551424 + 210 WP_001676010.1 hypothetical protein -
LJF57_RS07270 1551345..1551915 + 571 Protein_1402 integrase core domain-containing protein -
LJF57_RS07275 1552678..1553175 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1542718..1560013 17295
flank IS/Tn - - 1551637..1551915 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221417 WP_000994230.1 NZ_CP085796:c1548279-1548022 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221417 NZ_CP117390:c991315-990788 [Salmonella enterica subsp. enterica serovar Uganda]
ATGATGTTTACAGAATGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGCGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTGTGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 333 bp

>AT221417 NZ_CP085796:1548104-1548436 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References