202554

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3588284..3588698 Replicon chromosome
Accession NZ_CP074661
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN008104

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag A9D71_RS17535 Protein ID WP_000994230.1
Coordinates 3588441..3588698 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3588284..3588616 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D71_RS17495 3583545..3584042 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
A9D71_RS17500 3584805..3585375 - 571 Protein_3435 integrase core domain-containing protein -
A9D71_RS17505 3585296..3585505 - 210 WP_001676010.1 hypothetical protein -
A9D71_RS17510 3585558..3585872 + 315 WP_072100769.1 SymE family type I addiction module toxin -
A9D71_RS17515 3585939..3586217 - 279 WP_012543321.1 hypothetical protein -
A9D71_RS17520 3586534..3587001 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
A9D71_RS17525 3586998..3587315 - 318 WP_001751277.1 hypothetical protein -
A9D71_RS17530 3587873..3588106 - 234 WP_124084119.1 hypothetical protein -
- 3588284..3588616 - 333 - - Antitoxin
A9D71_RS17535 3588441..3588698 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
A9D71_RS17540 3588764..3589210 - 447 WP_000171102.1 hypothetical protein -
A9D71_RS17545 3589207..3590199 - 993 Protein_3444 RHS domain-containing protein -
A9D71_RS17550 3590644..3591165 - 522 WP_000968384.1 DUF2778 domain-containing protein -
A9D71_RS17555 3591189..3591485 - 297 Protein_3446 DUF2195 family protein -
A9D71_RS17560 3591485..3592261 + 777 Protein_3447 type VI secretion system baseplate subunit TssG -
A9D71_RS17565 3592272..3593327 + 1056 WP_000367631.1 ImpA family type VI secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3575650..3591461 15811
flank IS/Tn - - 3584805..3585083 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T202554 WP_000994230.1 NZ_CP074661:3588441-3588698 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T202554 NZ_CP099502:2614409-2614771 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 333 bp

>AT202554 NZ_CP074661:c3588616-3588284 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References