Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
Location | 3736500..3736914 | Replicon | chromosome |
Accession | NZ_CP117359 | ||
Organism | Salmonella enterica subsp. enterica serovar Dublin strain RM094 |
Toxin (Protein)
Gene name | IasE | Uniprot ID | M7RBD3 |
Locus tag | PQP87_RS18615 | Protein ID | WP_000994230.1 |
Coordinates | 3736657..3736914 (+) | Length | 86 a.a. |
Antitoxin (RNA)
Gene name | IsrA | ||
Locus tag | - | ||
Coordinates | 3736500..3736832 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PQP87_RS18575 | 3731761..3732213 | - | 453 | WP_001675682.1 | Saf-pilin pilus formation protein SafA | - |
PQP87_RS18580 | 3733022..3733592 | - | 571 | Protein_3637 | integrase core domain-containing protein | - |
PQP87_RS18585 | 3733513..3733722 | - | 210 | WP_001676010.1 | hypothetical protein | - |
PQP87_RS18590 | 3733775..3734089 | + | 315 | WP_072100769.1 | SymE family type I addiction module toxin | - |
PQP87_RS18595 | 3734156..3734434 | - | 279 | WP_012543321.1 | hypothetical protein | - |
PQP87_RS18600 | 3734750..3735217 | - | 468 | WP_000828183.1 | sugar tyrosine-protein kinase | - |
PQP87_RS18605 | 3735214..3735531 | - | 318 | WP_001751277.1 | hypothetical protein | - |
PQP87_RS18610 | 3736089..3736322 | - | 234 | WP_124084119.1 | hypothetical protein | - |
- | 3736500..3736832 | - | 333 | - | - | Antitoxin |
PQP87_RS18615 | 3736657..3736914 | + | 258 | WP_000994230.1 | SymE family type I addiction module toxin | Toxin |
PQP87_RS18620 | 3736980..3737426 | - | 447 | WP_000171102.1 | hypothetical protein | - |
PQP87_RS18625 | 3737423..3740245 | - | 2823 | Protein_3646 | RHS repeat-associated core domain-containing protein | - |
PQP87_RS18630 | 3740236..3740502 | + | 267 | WP_223151220.1 | SymE family type I addiction module toxin | - |
PQP87_RS18635 | 3740620..3740958 | - | 339 | WP_000201550.1 | hypothetical protein | - |
PQP87_RS18640 | 3740980..3741300 | - | 321 | WP_016695071.1 | HNH endonuclease | - |
PQP87_RS18645 | 3741358..3741641 | - | 284 | Protein_3650 | RHS repeat-associated core domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 3723866..3742194 | 18328 | |
flank | IS/Tn | - | - | 3733022..3733300 | 278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9490.94 Da Isoelectric Point: 9.5519
>T270793 WP_000994230.1 NZ_CP117359:3736657-3736914 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV
Download Length: 258 bp
Antitoxin
Download Length: 333 bp
>AT270793 NZ_CP117359:c3736832-3736500 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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