Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3736500..3736914 Replicon chromosome
Accession NZ_CP117359
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM094

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag PQP87_RS18615 Protein ID WP_000994230.1
Coordinates 3736657..3736914 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3736500..3736832 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP87_RS18575 3731761..3732213 - 453 WP_001675682.1 Saf-pilin pilus formation protein SafA -
PQP87_RS18580 3733022..3733592 - 571 Protein_3637 integrase core domain-containing protein -
PQP87_RS18585 3733513..3733722 - 210 WP_001676010.1 hypothetical protein -
PQP87_RS18590 3733775..3734089 + 315 WP_072100769.1 SymE family type I addiction module toxin -
PQP87_RS18595 3734156..3734434 - 279 WP_012543321.1 hypothetical protein -
PQP87_RS18600 3734750..3735217 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
PQP87_RS18605 3735214..3735531 - 318 WP_001751277.1 hypothetical protein -
PQP87_RS18610 3736089..3736322 - 234 WP_124084119.1 hypothetical protein -
- 3736500..3736832 - 333 - - Antitoxin
PQP87_RS18615 3736657..3736914 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
PQP87_RS18620 3736980..3737426 - 447 WP_000171102.1 hypothetical protein -
PQP87_RS18625 3737423..3740245 - 2823 Protein_3646 RHS repeat-associated core domain-containing protein -
PQP87_RS18630 3740236..3740502 + 267 WP_223151220.1 SymE family type I addiction module toxin -
PQP87_RS18635 3740620..3740958 - 339 WP_000201550.1 hypothetical protein -
PQP87_RS18640 3740980..3741300 - 321 WP_016695071.1 HNH endonuclease -
PQP87_RS18645 3741358..3741641 - 284 Protein_3650 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3723866..3742194 18328
flank IS/Tn - - 3733022..3733300 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T270793 WP_000994230.1 NZ_CP117359:3736657-3736914 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT270793 NZ_CP117359:c3736832-3736500 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References