203111

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3658642..3659056 Replicon chromosome
Accession NZ_CP075127
Organism Salmonella enterica strain CFSAN044925

Toxin (Protein)


Gene name IasE Uniprot ID A0A5Y7XEW6
Locus tag A7S47_RS17885 Protein ID WP_000994226.1
Coordinates 3658799..3659056 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3658642..3658974 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S47_RS17855 3654133..3654873 - 741 WP_043986360.1 pili assembly chaperone SafB -
A7S47_RS17860 3654953..3655450 - 498 WP_070793508.1 Saf-pilin pilus formation protein SafA -
A7S47_RS17865 3655583..3656077 - 495 WP_070793507.1 hypothetical protein -
A7S47_RS17870 3656946..3657647 - 702 Protein_3518 integrase core domain-containing protein -
A7S47_RS17875 3657700..3658014 + 315 WP_023892102.1 SymE family type I addiction module toxin -
A7S47_RS17880 3658081..3658359 - 279 WP_012664366.1 hypothetical protein -
- 3658642..3658974 - 333 - - Antitoxin
A7S47_RS17885 3658799..3659056 + 258 WP_000994226.1 SymE family type I addiction module toxin Toxin
A7S47_RS17890 3659147..3659524 - 378 WP_000739708.1 Imm8 family immunity protein -
A7S47_RS17895 3659844..3660005 - 162 WP_001658759.1 RHS repeat-associated core domain-containing protein -
A7S47_RS17900 3660178..3660516 - 339 WP_000357802.1 hypothetical protein -
A7S47_RS17905 3660783..3661094 - 312 WP_001220174.1 hypothetical protein -
A7S47_RS17910 3661114..3662049 - 936 Protein_3526 RHS domain-containing protein -
A7S47_RS17915 3662067..3662495 - 429 Protein_3527 DUF1795 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3656946..3657224 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9547.82 Da        Isoelectric Point: 5.0770

>T203111 WP_000994226.1 NZ_CP075127:3658799-3659056 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGRSVTVKISQECIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Download         Length: 258 bp

>T203111 NZ_CP099880:2494280-2494666 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTTATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCTGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 333 bp

>AT203111 NZ_CP075127:c3658974-3658642 [Salmonella enterica]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y7XEW6

Antitoxin

Download structure file

References