276150

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3659483..3659915 Replicon chromosome
Accession NZ_CP121262
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag P8621_RS18040 Protein ID WP_000994224.1
Coordinates 3659640..3659915 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3659483..3659905 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8621_RS18010 3655701..3656438 - 738 WP_001535430.1 pili assembly chaperone SafB -
P8621_RS18015 3656522..3657034 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
P8621_RS18020 3657784..3658488 - 705 Protein_3521 integrase core domain-containing protein -
P8621_RS18025 3658541..3658789 + 249 WP_001738030.1 SymE family type I addiction module toxin -
P8621_RS18030 3658891..3659199 - 309 WP_080247984.1 hypothetical protein -
P8621_RS18035 3659282..3659398 - 117 WP_227457392.1 hypothetical protein -
- 3659483..3659905 - 423 - - Antitoxin
P8621_RS18040 3659640..3659915 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
P8621_RS18045 3659968..3660405 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
P8621_RS18050 3660968..3661414 - 447 WP_000935097.1 protein SciX -
P8621_RS18055 3661408..3662277 - 870 Protein_3528 polymorphic toxin type 47 domain-containing protein -
P8621_RS18060 3662341..3662604 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3648631..3662604 13973
flank IS/Tn - - 3657784..3658065 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T276150 WP_000994224.1 NZ_CP121262:3659640-3659915 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT276150 NZ_CP121262:c3659905-3659483 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References