Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
| Location | 3689206..3689638 | Replicon | chromosome |
| Accession | NZ_CP099705 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain 013+ | ||
Toxin (Protein)
| Gene name | IasE | Uniprot ID | E8XIW0 |
| Locus tag | NG892_RS18220 | Protein ID | WP_000994224.1 |
| Coordinates | 3689363..3689638 (+) | Length | 92 a.a. |
Antitoxin (RNA)
| Gene name | IsrA | ||
| Locus tag | - | ||
| Coordinates | 3689206..3689628 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NG892_RS18190 | 3685424..3686161 | - | 738 | WP_001535430.1 | pili assembly chaperone SafB | - |
| NG892_RS18195 | 3686245..3686757 | - | 513 | WP_010988970.1 | Saf-pilin pilus formation protein SafA | - |
| NG892_RS18200 | 3687507..3688211 | - | 705 | Protein_3558 | integrase core domain-containing protein | - |
| NG892_RS18205 | 3688264..3688512 | + | 249 | WP_001738030.1 | SymE family type I addiction module toxin | - |
| NG892_RS18210 | 3688614..3688922 | - | 309 | WP_080247984.1 | hypothetical protein | - |
| NG892_RS18215 | 3689005..3689121 | - | 117 | WP_227457392.1 | hypothetical protein | - |
| - | 3689206..3689628 | - | 423 | - | - | Antitoxin |
| NG892_RS18220 | 3689363..3689638 | + | 276 | WP_000994224.1 | SymE family type I addiction module toxin | Toxin |
| NG892_RS18225 | 3689691..3690128 | - | 438 | WP_000943619.1 | immunity 26/phosphotriesterase HocA family protein | - |
| NG892_RS18230 | 3690691..3691137 | - | 447 | WP_000935097.1 | protein SciX | - |
| NG892_RS18235 | 3691131..3692000 | - | 870 | Protein_3565 | polymorphic toxin type 47 domain-containing protein | - |
| NG892_RS18240 | 3692064..3692327 | - | 264 | WP_000932531.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | - | 3678354..3692327 | 13973 | ||
| flank | IS/Tn | - | - | 3687507..3687788 | 281 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10032.36 Da Isoelectric Point: 6.4704
>T249300 WP_000994224.1 NZ_CP099705:3689363-3689638 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
Download Length: 276 bp
Antitoxin
Download Length: 423 bp
>AT249300 NZ_CP099705:c3689628-3689206 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
