294616

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1982156..1982588 Replicon chromosome
Accession NZ_OU015323
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag KKQ99_RS10355 Protein ID WP_000994224.1
Coordinates 1982313..1982588 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1982156..1982578 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ99_RS10325 1978374..1979111 - 738 WP_001535430.1 pili assembly chaperone SafB -
KKQ99_RS10330 1979195..1979707 - 513 WP_077248260.1 pilus assembly protein -
KKQ99_RS10335 1980457..1981161 - 705 Protein_2040 integrase core domain-containing protein -
KKQ99_RS10340 1981214..1981462 + 249 WP_001738030.1 SymE family type I addiction module toxin -
KKQ99_RS10345 1981564..1981872 - 309 WP_010988969.1 hypothetical protein -
KKQ99_RS26475 1981955..1982071 - 117 WP_227457392.1 hypothetical protein -
- 1982156..1982578 - 423 - - Antitoxin
KKQ99_RS10355 1982313..1982588 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
KKQ99_RS10360 1982641..1983078 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
KKQ99_RS10365 1983641..1984087 - 447 WP_000935097.1 protein SciX -
KKQ99_RS10370 1984081..1984950 - 870 Protein_2047 polymorphic toxin type 47 domain-containing protein -
KKQ99_RS10375 1985014..1985277 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1971304..1985277 13973
flank IS/Tn - - 1980457..1980738 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T294616 WP_000994224.1 NZ_OU015323:1982313-1982588 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT294616 NZ_OU015323:c1982578-1982156 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References