251140

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3689586..3690018 Replicon chromosome
Accession NZ_CP100707
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0409

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NL735_RS18300 Protein ID WP_000994224.1
Coordinates 3689743..3690018 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3689586..3690008 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL735_RS18270 3685804..3686541 - 738 WP_001535430.1 pili assembly chaperone SafB -
NL735_RS18275 3686625..3687137 - 513 WP_077248260.1 pilus assembly protein -
NL735_RS18280 3687887..3688591 - 705 Protein_3576 integrase core domain-containing protein -
NL735_RS18285 3688644..3688892 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NL735_RS18290 3688994..3689302 - 309 WP_010988969.1 hypothetical protein -
NL735_RS18295 3689385..3689501 - 117 WP_227457392.1 hypothetical protein -
- 3689586..3690008 - 423 - - Antitoxin
NL735_RS18300 3689743..3690018 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NL735_RS18305 3690071..3690508 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NL735_RS18310 3691071..3691517 - 447 WP_000935097.1 protein SciX -
NL735_RS18315 3691511..3692380 - 870 Protein_3583 polymorphic toxin type 47 domain-containing protein -
NL735_RS18320 3692444..3692707 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3678734..3692707 13973
flank IS/Tn - - 3687887..3688168 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T251140 WP_000994224.1 NZ_CP100707:3689743-3690018 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT251140 NZ_CP100707:c3690008-3689586 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References