221316

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 2689285..2689699 Replicon chromosome
Accession NZ_CP085792
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Mightyena

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF62_RS12675 Protein ID WP_000994230.1
Coordinates 2689285..2689542 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 2689367..2689699 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF62_RS12660 2684896..2685402 + 507 Protein_2450 phage late control D family protein -
LJF62_RS12665 2685402..2688776 + 3375 Protein_2451 RHS domain-containing protein -
LJF62_RS12670 2688773..2689219 + 447 WP_000171102.1 hypothetical protein -
LJF62_RS12675 2689285..2689542 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 2689367..2689699 + 333 - - Antitoxin
LJF62_RS12680 2689877..2690110 + 234 WP_124084119.1 hypothetical protein -
LJF62_RS12685 2690668..2690985 + 318 WP_001751277.1 hypothetical protein -
LJF62_RS12690 2690982..2691449 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF62_RS12695 2691766..2692044 + 279 WP_012543321.1 hypothetical protein -
LJF62_RS12700 2692111..2692425 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF62_RS12705 2692478..2692687 + 210 WP_001676010.1 hypothetical protein -
LJF62_RS12710 2692608..2693178 + 571 Protein_2460 integrase core domain-containing protein -
LJF62_RS12715 2693941..2694438 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2683981..2703072 19091
flank IS/Tn - - 2692900..2693178 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221316 WP_000994230.1 NZ_CP085792:c2689542-2689285 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221316 NZ_CP117376:312745-313113 [Salmonella enterica subsp. enterica serovar Newport]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 333 bp

>AT221316 NZ_CP085792:2689367-2689699 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References